Finalists

Innovators

Seventy-seven finalists out of over 600 applications were selected to compete in the final stage of the Saving Lives at Birth program.  We received applications from across the globe – including from non-profits, faith based organizations, universities, and private enterprises – spanning a wide range of solutions.   The innovators traveled to Washington July 26-28, 2011 to participate in the Saving Lives at Birth DevelopmentXChange where the top 19 nominees for seed awards were announced.

 Saving Lives at Birth innovators

19 AWARD NOMINEES (SEED GRANTS)*

Operative Experience from Elkton, MD for its simulation based training for emergency C-section.

Healthpoint Services from Secunderabad, India to apply low cost health and information technologies at the community and clinic level for integrated maternal and neonatal health delivery in rural India.

Program for Appropriate Technology in Health from Seattle, Washington to increase accessibility to less invasive lung support equipment for neonates in low-resource settings.

Baylor College of Medicine in Houston, TX for primary prevention of periodontal disease in relation to preterm birth in Malawi.

Moi University School of Medicine in Eldoret, Kenya for improving community-based accountability for maternal and newborn health. 

Monash University from Clayton, Australia for an alternative means of delivering oxytocin to women in resource-poor countries.

Jhpiego Corporation from Baltimore, Maryland for its innovative development of an e-partogram. 

Duke University from Durham, North Carolina for its innovation to reduce mother-to-child transmission of HIV. 

Zoe Alexander from Nairobi, Kenya for its novel mobile application. 

The University of British Colombia from Vancouver, Canada for their innovative phone oximeter.  

Save the Children Federation from Westport, Connecticut for their human energy-powered fetal heart rate monitor and phone-based mortality audit.

Population Council from New York City for its mobile clinical assessment service called Baby Monitor.

The Johns Hopkins University from Baltimore, Maryland for their easy-to-use identification system for early and late preterm infants.

The World Health Organization in Geneva, Switzerland for their simple, low-cost instrument for assisted vaginal delivery. 

Diagnostics for All, Inc. from Cambridge, MA for their proposal to develop low-cost, point-of-care microfluidic diagnostics.  

Partners for Development from Silver Spring, Maryland for their reliable, market-driven emergency transport solution for pregnant women. 

Hospital for Sick Children from Toronto, Canada for their innovative approach to supply micronutrients to pregnant women.  

Fincon from Islamabad, Pakistan for their micro health franchise system.

William Marsh Rice University from Houston, Texas for its low-cost, bubble continuous positive airway pressure system or bCPAP.  

* Nominees will enter into final negotiations on their grants before awards can be issued.  Nominees for transition grant awards will be made at a later date.

 

VIEW ALL 77 FINALISTS

Project Organization Organization Location
Development of nanodevice for the detection of pro-inflammatory markers for the diagnosis of sepsis

We aim to develop and field test (limited) a rapid diagnostic test using a nanodevice for detecting bacterial sepsis in neonates and young children. This test will identify inflammatory and bacterial surface markers of bacterial sepsis in the blood. The goal is its use in the field by community health workers (CHWs) to assist in the safe management of neonatal sepsis. It is cheap (<$1 per test), rapid (<30 minutes), and since the readout is visual, its use will not require specialized training.

Development of nanodevice for the detection of pro-inflammatory markers for the diagnosis of sepsis
Sri Narayani Hospital and Research Centre Vellore, India
Intrauterine application of a kaolin-based hemostatic agent for PPH

In developing countries Post Partum Hemorrhage (PPH) is the single most common cause of maternal morbidity and mortality and accounts for approximately 25 percent of maternal deaths globally. We propose to use an existing technology called QuikClot as a safe, effective, simple to use and low cost form of treatment for PPH. QuikClot is a hemostatic gauze containing kaolin, an inert mineral that promotes blood clotting; currently QuikClot is the main hemostatic device used by all branches of the US Military to control bleeding following war injuries.

Intrauterine application of a kaolin-based hemostatic agent for PPH
Z-Medica Corporation Wallingford, CT USA
Power for Health (PFH)

Most rural health facilities in Uganda and many parts of Africa have no electricity, lighting or phones to communicate with clients or doctors, which contributes to low uptake of antenatal and maternity services and unsafe care for pregnant women who deliver there. Power for Life (PFH) will conduct a case-control study in 12 rural health centers in 2 districts of Uganda to test the idea that: a) supplying solar power and lighting, and b) providing data and voice technology will improve health seeking behavior, quality of care during childbirth, and birth outcomes.

Power for Health (PFH)
Communication for Development Foundation Uganda (CDFU) Kampala, Uganda
A compact, low cost system for nitric oxide inhalation therapy

A recent UNICEF report states:  Pneumonia kills more children than any other disease  more then AIDS, malaria, and measles combined. Our focus is on the introduction of new technology that will make available proven and newly emerging treatments for a variety of respiratory disorders affecting infants in low resource settings.

A compact, low cost system for nitric oxide inhalation therapy
Whalen Biomedical Inc. Lexington, MA USA
A unique, portable, noninvasive maternal anemia screening technology

Anemia is a silent killer that continues to be a major risk factor for millions of pregnant women and their newborns. Anemia places women at risk for poor pregnancy outcomes including increased risk of mortality and morbidity, preterm births, and low birth weight babies. The majority of these women live in rural areas with little access to proper care. Early detection, monitoring, and treatment of anemia in women during pregnancy, at labor, and in the first 48 hours after delivery could lead to life-saving interventions and significant cost savings to health systems.

A unique, portable, noninvasive maternal anemia screening technology
Program for Appropriate Technology in Health (PATH) Seattle, WA USA
Vaccines to Blood: Adapting Innovative Cold Chain Technologies for Storage of Safe Blood

Well-funded, effective vaccine initiatives have developed important technologies that can positively impact other health care sectors. The challenge is to clearly identify and proactively exploit the most promising "spin-off" opportunities early on. By redirecting recent innovations in vaccine cold chain toward safe blood storage, we anticipate an immediate, life-saving impact for women experiencing obstetric emergencies. They might otherwise die from lack of available blood or from bacterial and viral infections resulting from improper storage conditions or infected donor blood.

Vaccines to Blood: Adapting Innovative Cold Chain Technologies for Storage of Safe Blood
Program for Appropriate Technology in Health (PATH) Seattle, WA USA
Improving Health Service Delivery Through Community Monitoring and Non-Financial Awards

Sierra Leone ranks close to last in the UN Human Developing Index, and faces exorbitant rates of maternal and child mortality. As in other least developed nations, poor service delivery including weak incentives for health workers contributes to these outcomes, through problems such as worker absenteeism and low clinic utilization rates. We seek to examine how two types of social accountability interventions can improve health service delivery and outcomes for women and children under five. Our randomized control trial implements the interventions via a cross-cutting design.

Improving Health Service Delivery Through Community Monitoring and Non-Financial Awards
Innovations for Poverty Action New Haven, CT USA
Reducing Maternal and Newborn Infections with an Energy Generating Incinerator

Jhpiego, in partnership with the Community Cooker Foundation (CCF), proposes modifying a proven cost-effective and environmentally safe innovation, the Community Cooker (CC), for waste disposal in health care settings in Kenya.  Maternity wards are one of the highest producers of medical waste. Unsafe disposal of medical waste in health facilities can lead to life-threatening infections including sepsis, Hepatitis B, Hepatitis C, HIV and others. Fifteen percent of maternal deaths and 25% of neonatal deaths are due to sepsis and other infections.

Reducing Maternal and Newborn Infections with an Energy Generating Incinerator
Jhpiego Corporation Baltimore, MD, USA
Inexpensive, hand held early warning and detection system for preeclampsia

Preeclampsia is a major cause of maternal and neonatal death, particularly in low-income and developing countries. When treated properly the mortality rate is low. Unfortunately many women in low-income countries do not have ready access to proper care. Our research has shown that we can reliably detect preeclampsia 10-12 weeks before the onset of symptoms. We propose to create an inexpensive, easy-to-use, handheld system that detects the likelihood of the future onset of preeclampsia. A 50-patient clinical study will validate its effectiveness.

Inexpensive, hand held early warning and detection system for preeclampsia
Convergent Engineering Inc. Newberry, FL, USA
A low-cost, electricity free Oxygen concentrator

Pneumonia alone contributes to between 750,000 and 1.2 million neonatal deaths and an unknown number of stillbirths each year world-wide. Provision of oxygen has the potential for large reductions in neonatal and child mortality due to prematurity, birth asphyxia, and other causes. At the level of the small district hospital and sub-district health center there is a major equity issue, as current oxygen provision methods require reliable electricity, which is typically unavailable.

A low-cost, electricity free Oxygen concentrator
The University of Melbourne Melbourne, Victoria, Australia
An Integrated Program for Postpartum Hemorrhage Prevention and Management in Ghana

Obstetric hemorrhage contributes to a significant proportion of maternal death and disability in Ghana. The project utilizes a postpartum hemorrhage (PPH) prevention and management strategy developed by in-country stakeholders, facilitated by PATH, and led by the Ghana Health Service. The proposed project will undertake a controlled introduction of an innovative technology-intervention bundle for the prevention and management of PPH.

An Integrated Program for Postpartum Hemorrhage Prevention and Management in Ghana
PATH Seattle, WA, USA
Improving Maternal & Child Care via Community-Based Health Insurance and Quality Improvement Mechanisms in Kwara State, Nigeria

The overarching focus of PharmAccess is on improving access to affordable and quality maternal and child health care for low-income families in Nigeria. The essence of PharmAccess comprises an integrated approach of complementary initiatives that increase resources, efficiency and effectiveness within the healthcare system. Through quality improvement, loans for healthcare providers, and health insurance, the demand for and supply of care is stimulated.

Improving Maternal & Child Care via Community-Based Health Insurance and Quality Improvement Mechanisms in Kwara State, Nigeria
PharmAccess Foundation Amsterdam, the Netherlands
Antenatal Intervention Demand Card (AID-Card) and a phone based surveillance system

Shortage of medical resources in rural Uganda leads to inconsistencies in provision of antenatal care (ANC) interventions. Mbarara University and Ibanda district health team propose to enhance delivery and uptake of ANC interventions by harnessing the power of cell phone technology widely available in rural Uganda. We aim to increase the demand for ANC with a pictorial Antenatal Intervention Demand Card (AID-Card) that will be linked to a cell phone data capture and surveillance system. The pictorial representations in the AID-Card will be developed in consultation with the community.

Antenatal Intervention Demand Card (AID-Card) and a phone based surveillance system
Mbarara University of Science and Technology Mbarara, Uganda
Mini-Blood Banks for Life Saving Red Blood Cells: Where Needed & When Needed

The statistics are clear. Over one third of all maternal mortality in the developing world results from hemorrhage. Compounding this problem and contributing significantly to the death rate are very difficult transportation logistics from remote rural regions to key national medical centers, and endemic anemia in the female population. The availability of transfusable packs of life saving Red Blood Cells in these remote locations is nearly completely absent.

Mini-Blood Banks for Life Saving Red Blood Cells: Where Needed & When Needed
Hemacon GmbH Duesseldorf, Germany
Rolling out chlorhexidine for umbilical cord care in Bangladesh and beyond

Globally, newborn sepsis is the cause of over 500,000 of the 3.1 million newborn deaths each year. Applying a 4% chlorhexidine product (7.1% chlorhexidine digluconate) to the umbilical cord saves newborn lives and is a cost-effective intervention. Data from Bangladesh, Nepal, and Pakistan demonstrated an aggregate 23% reduction in neonatal mortality (not including deaths in the first few hours of life) and a 68% reduction in severe infections for the chlorhexidine intervention groups.

Rolling out chlorhexidine for umbilical cord care in Bangladesh and beyond
Program for Appropriate Technology in Health (PATH) Seattle, WA USA
Mobile Lotteries for Safe Births: Accelerating Scale up of the Demand Driven Safe Motherhood Voucher Program in Uganda

In this decade, maternal and reproductive health voucher programs have contributed to reduced maternal and infant mortality and morbidity. The Uganda program is considered a key success. The administrative cost of supporting these safe births is approximately 32% of total program costs. 

Mobile Lotteries for Safe Births: Accelerating Scale up of the Demand Driven Safe Motherhood Voucher Program in Uganda
Population Council New York, NY USA
Strenthening maternal health care delivery through e-learning

The world is facing a shortage of 4.3 million health workers, with every region except Europe showing a shortfall. Rapid urbanization in developing countries is exacerbating shortage of health workers in rural areas, as trained professionals seek work in more affluent urban conurbations.

Strenthening maternal health care delivery through e-learning
Hindustan Latex Family Planing Promotion Trust Noida, India
An Effective, Safe and Convenient Approach to Treat Pre-term Birth

The objective of this proposal is to develop an effective, conveniently administered, low-cost, topical, semi-solid, room-temperature-stable, progestin-containing product for the treatment of preterm birth (PTB). Progestins have been demonstrated to help prevent recurrent preterm labor and decrease PTB rates in high-risk women. Clinical studies have indicated that women treated with naturally occurring progesterone (P4) have reduced rates of PTB. Women with a history of PTB and those found to have a short cervix now often receive P4 off-label throughout their pregnancies.

An Effective, Safe and Convenient Approach to Treat Pre-term Birth
Evestra, Inc. San Antonio, TX, USA
Treatment of Maternal Hemorrhage using OxyVita

OXYVITA Inc. has developed a powder form of its transfusible hemoglobin based oxygen carrier. This product has undergone initial testing in an animal hemorrhage model with success, making the product the first powder form of a red blood cell transfusion alternative in the world. In third world settings where the greatest percentage of maternal hemorrhage death occurs, ease of administration of the product is vital. Currently, our product is designed for use in a hospital setting, however, its real benefit is that it can be used in remote locations, injected on site by a medic or midwife.

Treatment of Maternal Hemorrhage using OxyVita
OXYVITA Inc New Windsor, NY USA
IVR4BABY - Afghanistan

Ten years after the ouster of the Taliban, Afghanistan's maternal mortality rates are still among the world's highest, accounting for over five percent of all annual maternal deaths across the globe. Neonatal mortality is equally abysmal, and fragile gains in the sector remain hindered by severe coverage and access gaps arising from structural capacity constraints and a dearth of skilled midwives providing basic health education to expectant mothers in isolated rural areas. Gender repression and cultural perceptions pose additional challenges.

IVR4BABY - Afghanistan
International Synergy Group, LLC, in partnership with Medweb Niceville, FL USA
mHealth for Safer Deliveries

While there has been a considerable decrease in child mortality in most sub-Saharan African countries over the past two decades, neonatal and maternal mortality have changed little. There is substantial evidence that facility-based deliveries lead to lower mortality rates for both mother and infant.

mHealth for Safer Deliveries
D-Tree International, Inc Weston, MA, USA
Scaling the Pratt Pouch for the Prevention of Transmission of HIV from Mother to Child

We propose transitioning the Pratt Pouch to scale in Zambia. We will train PMTCT healthcare workers in selected (42 of 72) districts, such that 80% of HIV+, pregnant, Zambian women at risk of delivering at home will receive antiretroviral drugs (ARVs) for their child. Approximately 200 pharmacists, 200 nurses and 400 lay counselors will be trained.

Scaling the Pratt Pouch for the Prevention of Transmission of HIV from Mother to Child
Duke University Durham, NC, USA
Globalization of m4RH: Increasing Evidence, Expanding Implementation, and Modeling Sustainability to Improve Health and Save Lives

Healthy timing and spacing of pregnancies can reduce deaths among children under age five by one-third. Preventing unplanned pregnancies can eliminate up to 40 percent of maternal deaths. The Mobile for Reproductive Health (m4RH) program has the potential to dramatically increase contraceptive use among women in countries with the greatest need.

Globalization of m4RH: Increasing Evidence, Expanding Implementation, and Modeling Sustainability to Improve Health and Save Lives
Family Health International (FHI 360) Durham, NC, USA
Reinvigorating the Postpartum IUD Using a Low-Cost Simulation Model

Despite efforts to reinvigorate use of the postpartum intrauterine device (PPIUD) as a way to prevent adverse maternal and newborn health outcomes due to poor birth spacing, PPIUDs are underutilized due to lack of provider confidence, client mistrust of the method and systemic conditions that limit the number of providers trained. Current PPIUD training models are expensive, heavy and not designed to simulate a variety of uterine positions.

Reinvigorating the Postpartum IUD Using a Low-Cost Simulation Model
Jhpiego Corporation Baltimore, MD USA
Improving Governance and Health Outcomes for the Poor Through Innovative Technology

Women’s health in India is neglected because the public health system is not functioning properly. A recent study found that nearly 40 percent of health staff in India are absent from work on a typical day; and it gets worse in rural areas. This problem negatively affects both the way women use health facilities and their health outcomes: Only 18 percent of births take place in a public facility, and the neonatal mortality rate in India is almost 40 percent.

Improving Governance and Health Outcomes for the Poor Through Innovative Technology
Poverty Action Lab Chennai, India
PharmaCheck: Counterfeit and Substandard Drug Detector Device for the Developing World

Malaria affects over 50% of the populace in sub-Saharan Africa, and contributes to over 200,000 newborn and 10,000 maternal deaths annually worldwide. In 2008, maternal sepsis accounted for 36,000 deaths while neonatal infection caused close to a million neonatal deaths. It is estimated that between 10-30% of drug sales are counterfeit in parts of Africa, Asia, and Latin America - and between 30-50% of all anti-malarials are substandard.

PharmaCheck: Counterfeit and Substandard Drug Detector Device for the Developing World
Trustees of Boston University Boston, MA USA
A Quality Improvement Toolkit to Improve Care Between Urban Communities and Facilities

A high maternal mortality rate persists in peri-urban Kenya, at 700 deaths per 100,000 live births. The quality of facility-based care remains poor, and is recognized by the maternal health community as a significant barrier to improving maternal and neonatal outcomes. Jacaranda Health is a growing network of maternity hospitals building better systems for delivering affordable, high-quality care. We propose to craft a Lean Management-based quality improvement toolkit for use in low-resource settings like ours.

A Quality Improvement Toolkit to Improve Care Between Urban Communities and Facilities
Jacaranda Health Nairobi, Kenya
WiseMama Zambia: Feasibility, Acceptability and Preliminary Effect of Wireless Technology to Improve Adherence to Antiretroviral Therapy in Pregnant and Postpartum Women

Antiretroviral therapy (ART) improves health and long-term survival of people living with HIV, but only if high adherence is maintained. Several studies have found perilously low ART adherence in pregnant and postpartum women (PPPW), the consequences which are dire: disease progression and death in women; HIV infection, death and orphanhood for babies; and a rise in drug resistant HIV.

WiseMama Zambia: Feasibility, Acceptability and Preliminary Effect of Wireless Technology to Improve Adherence to Antiretroviral Therapy in Pregnant and Postpartum Women
Trustees of Boston University, BUMC Boston, MA, USA
E-Partogram

Jhpiego and its partners (Johns Hopkins University Center for Bioengineering Innovation and Design and Laerdal Global Health) propose to rapidly develop and conduct initial field-testing for an “E-Partogram,” an affordable, easy-to-use, handheld electronic decision-making tool for preventing or managing complications during labor. The E-partogram could positively transform safe childbirth by enabling front-line providers to more rapidly assess and respond to labor complications and receive crucial guidance to save the lives of women and newborns.

E-Partogram
Jhpiego Corporation Baltimore, MD, USA
mHealth for Safer Deliveries

We provide a mobile phone based algorithm to assist midwives to quickly and accurately identify obstetric emergencies and arrange transportation for the pregnant woman to a health facility where she can receive appropriate care.

mHealth for Safer Deliveries
D-tree International, Inc Weston, MA USA
Transition to Scale of Brilliance, Phototherapy to Prevent Brain Damage and Death from Severe Neonatal Jaundice in India

Every year, extreme hyperbilirubinemia affects 23M infants globally, 90% from developing nations. Untreated hyperbilirubinemia can cause permanent brain damage (kernicterus) or death, making it the 5th leading cause of infant mortality. While phototherapy is a simple and effective treatment, nearly all solutions are too expensive and unsuitable for low-resource hospitals where the need is dire.

Transition to Scale of Brilliance, Phototherapy to Prevent Brain Damage and Death from Severe Neonatal Jaundice in India
D-Rev: Design Revolution San Francisco, CA, USA
Check2gether: Ensuring healthier pregnancies through testing and group care

In the Upper East region, Ghana, effective ANC delivery is hampered by low quality services and delayed ANC attendance by pregnant women, meaning high-risk pregnancies are not identified and treated in time. To tackle this problem and reduce maternal mortality, Simavi proposes combining group ANC with a non-invasive testing kit to diagnose (pre)eclampsia and anemia thus identifying high-risk pregnancies during outreach and in community health centers.

Check2gether: Ensuring healthier pregnancies through testing and group care
Simavi Haarlem, the Netherlands
Transforming Maternal and Child Health and Wellness: The 1000 Days Initiative

The 1000 Days Initiative is a transformational approach to producing healthy mothers and live, thriving babies amongst economically vulnerable populations.  It replaces the compartmentalized efforts of the past with an integrated approach of wellness and health services over the course of a woman's pregnancy and the first two years of life.  It combines best practices for maternal and newborn care with the provision of nutrition, immunizations, and clean water in a single package.

Transforming Maternal and Child Health and Wellness: The 1000 Days Initiative
Public Health Foundation of India (PHFI) New Delhi, India
PIERS on the move: Pre-eclampsia Integrated Estimate of RiSk assessment on a mobile phone

There is an urgent need for low-cost, easy-to-use tools that can accurately predict adverse outcomes associated with pre-eclampsia (a major cause of maternal and perinatal mortality). We will develop a mobile phone application to be used by community health workers in rural, low-resource settings that a) provides local, rapid and accurate risk assessment, referral, and treatment advice for pre-eclampsia, and b) transmits information to referral centers for coordination of triage, transportation and treatment.

PIERS on the move: Pre-eclampsia Integrated Estimate of RiSk assessment on a mobile phone
The University of British Columbia Vancouver, BC Canada
Novel frontline mobile diagnostics device for antenatal care

Early detection and treatment of sexually transmitted infections (such as congenital syphilis) in pregnant mothers is an extremely cost-effective measure to avoid adverse health consequences to both mothers and their children. However, despite their clinical importance, STI diagnostic tests are normally unavailable in rural regions. Here, we propose to scale up development and deploy in Rwandan community-level clinics a novel, low-cost, front-line diagnostic testing device that enables simultaneous detection of HIV and syphilis.

Novel frontline mobile diagnostics device for antenatal care
The Trustees of Columbia University in the City of New York New York, NY USA
Portable Remote Presence for Point-of-Care Prenatal Assessment

Rationale: Decrease maternal and newborn morbidity and mortality at childbirth in poor hard-to-reach populations.

Portable Remote Presence for Point-of-Care Prenatal Assessment
Queen Elizabeth II Health Sciences Centre, Capital Health District Authority Halifax, Nova Scotia Canada
Scaling-up Every Second Matters Uterine Balloon Tamponade System for Postpartum Hemorrhage in Kenya and Sierra Leone

Post-partum hemorrhage (PPH) is a leading killer of pregnant women worldwide. In resource-poor settings, especially in rural areas, many women lack access to quality, assisted delivery by skilled birth attendants, and therefore are at high risk for suffering injury or death consequent to PPH. Uterine balloon tamponade (UBT) has been shown to be an effective technique to treat uterine hemorrhage in developed countries, but has not been widely examined in resource-poor settings.

Scaling-up Every Second Matters Uterine Balloon Tamponade System for Postpartum Hemorrhage in Kenya and Sierra Leone
Massachusetts General Hospital Boston, MA, USA
Project mMitra: Voice messaging and animation service to improve MCH information access in rural India

mMitra is a free mobile voice messaging and animated film service in rural India that will provide culturally appropriate comprehensive information on preventive care and simple interventions during the perinatal period. The voice messages will be in the local dialect and specific to the woman's gestational age or the age of the newborn and will be sent weekly free of cost directly to pregnant women and mothers with newborns.

Project mMitra: Voice messaging and animation service to improve MCH information access in rural India
UCSF/Bixby Center/Safe Motherhood Program with ARMMAN San Francisco, CA USA
An affordable, biodegradable single-use lancet: increasing access for pregnant women and newborns to safe, point-of-care testing in resource-limited settings

Lack of access to laboratory testing for prevalent diseases in resource-limited settings is a major concern for maternal and newborn health. Although a market for affordable point-of-care testing is emerging, the price point for commercial single-use lancets is prohibitive for most countries. As a result, many healthcare providers are forced to choose between multiple uses of a lancet/needle and the inability to test for disease or administer medication. To solve this dilemma, we propose development of a low-cost (under 5 cents), biocompatible, biodegradable non-reusable lancet.

An affordable, biodegradable single-use lancet: increasing access for pregnant women and newborns to safe, point-of-care testing in resource-limited settings
Massachusetts General Hospital Boston, MA, USA
A simple, rapid assessment tool to identify and triage preterm infants

Preterm birth leads to more annual neonatal deaths (1 million) than any other single cause; these deaths primarily occur in low income settings where many infants are born at home and gestational age is rarely assessed. Innovative ways to identify preterm infants in the community are needed to facilitate rapid and appropriate targeting of interventions and referral.

A simple, rapid assessment tool to identify and triage preterm infants
The Johns Hopkins University Baltimore, MD, USA
Odon Device for Assisted Vaginal Delivery

Complications due to prolonged second stage of labor include potentially fatal maternal (hemorrhage, infection) and newborn complications (birth asphyxia and trauma).

Odon Device for Assisted Vaginal Delivery
World Health Organization Geneva, Switzerland
Micro Health Franchise System

Micro Health Franchise System empowers community midwife worker in providing high quality and cost effective healthcare services to mother and child in poor communities; at their door steps. Micro Health Franchise system also provides entrepreneurial support to the community midwife workers that lead to the standardization of services, access to financial services and having support by an efficient referral network that can respond to emergencies in a proactive manner. At the core of this solution lies the Telehealth module.

Micro Health Franchise System
FINCON Islamabad, Pakistan
HemoGlobe: Revitalizing Maternal Anemia Prevention and Treatment Globally

Anemia is a persistent global health problem affecting millions of mothers and newborns and contributing to 100,000 maternal and 600,000 newborn deaths annually. Despite massive global investments in nutritional and supplementation programs, continued high prevalence of maternal anemia has unfortunately relegated its status to routine. Jhpiego and the Johns Hopkins University Center for Bioengineering Innovation and Design are developing an innovative method to facilitate the dual goal of community-based screening and national-level anemia surveillance.

HemoGlobe: Revitalizing Maternal Anemia Prevention and Treatment Globally
Jhpiego Corporation Baltimore, MD USA
Information and communication technologies to support equity access to maternal and child care: EQUI-Transition

Pregnant women and newborns in sub-Saharan countries face unequal access to qualified health professionals and quality care, especially in rural communities. This has severe consequences on maternal and child mortality. Innovative solutions are urgently needed to save their lives This project aims to scale-up two promising interventions: 1) task delegation in obstetrical echography and 2) mobile technology to increase neonatal consultation in women who gave birth and follow-up of children under 5.

Information and communication technologies to support equity access to maternal and child care: EQUI-Transition
REIMICOM / CERTES Mali
Building and Sustaining Capacity of Frontline Health Workers in Prevention and Management of Postpartum Hemorrhage and Neonatal Asphyxia on the Day of Birth

Jhpiego proposes a capacity building and sustaining "Day of Birth" approach to bring lifesaving services to remote health facilities where complications must be prevented and managed simultaneously and swiftly, often by a single provider. This approach uses evidence-based practices in prevention and treatment of the two biggest killers of women and newborns in the hours after birth -PPH and neonatal asphyxia.

Building and Sustaining Capacity of Frontline Health Workers in Prevention and Management of Postpartum Hemorrhage and Neonatal Asphyxia on the Day of Birth
Jhpiego Corporation Baltimore, MD USA
Reducing Pre-Eclampsia Morbidity and Mortality in Resource-Limited Settings Through the Urine Congo Red Dot (CRD) Test

In limited-resource settings, morbidity and mortality from preeclampsia results from lack of/delayed diagnosis. Preeclampsia is a hypertensive proteinuric syndrome unique to human pregnancy. The problem is that neither hypertension nor proteinuria is sensitive or specific, especially in women with atypical presentations. We provided novel evidence that the urine of preeclamptic women is highly enriched in misfolded proteins. Based on this, we developed the Congo Red Dot (CRD) as a diagnostic and clinical prognostic tool for preeclampsia.

Reducing Pre-Eclampsia Morbidity and Mortality in Resource-Limited Settings Through the Urine Congo Red Dot (CRD) Test
The Research Institute at Nationwide Childrens Hospital Columbus, OH, USA
Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi

Adverse birth outcomes related to the length of gestation (preterm birth; PTB) and fetal growth (low birth weight or small for gestational age; SGA) are recognized as the two most significant disorders in maternal-child health at global scale. In the developed world, the preterm birth rate approximates 7%. In Malawi, this rate nearly triples to reliable estimates approximating 20.3%, and is felt to possibly occur as a result of maternal infection and inflammation.

Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi
Baylor College of Medicine Houston, TX USA
Development of a Simple Decision-Making Tool to Accurately Assess Excessive Blood Loss and Postpartum Hemorrhage at Childbirth

Obstetric hemorrhage is estimated to cause 25% of maternal deaths and is the leading direct cause of maternal mortality worldwide. Postpartum hemorrhage (PPH), characterized as severe bleeding in excess of 500 ml after the birth of a baby, accounts for the majority of hemorrhage cases and occurs in over 10% of births, with a 1% case-fatality rate. Maternal anemia, which affects up to half of all women globally, has long been purported as an underlying risk factor for PPH, and this assertion has been recently supported by evidence in Africa.

Development of a Simple Decision-Making Tool to Accurately Assess Excessive Blood Loss and Postpartum Hemorrhage at Childbirth
Program for Appropriate Technology in Health (PATH) Seattle, WA USA
Improved Capacity for Maternal and Child Care Delivery through Containerized Medical Clinics in Rural Namibia

Containers 2 Clinics (C2C), in partnership with The Synergos Institute and the Namibia Ministry of Health and Social Services (NMoHSS) will pilot a regional cluster of three state-of-the-art shipping container healthcare clinics, and provide comprehensive services, including clinical, lab, pharmacy and programming for women and children. The partnership will create access to high-quality primary healthcare and provide the NMoHSS a replicable, scalable solution for building national capacity in maternal and child health.

Improved Capacity for Maternal and Child Care Delivery through Containerized Medical Clinics in Rural Namibia
Containers 2 Clinics, Inc. (C2C) Dover, MA USA
Making Incentives Work: Using Mobile Vouchers to Improve Maternal Health in Cambodia

Mobile maternal health voucher programs have the potential to transform a novel incentive scheme into a cost effective and efficient way to spark an increase in the utilization of health services and to reduce maternal morbidity and mortality. Health voucher programs enable women to purchase vouchers for maternal health services at a fraction of the cost and redeem them at quality-accredited facilities, public or private. This innovative strategy has been being successfully piloted in several low-income countries.

Making Incentives Work: Using Mobile Vouchers to Improve Maternal Health in Cambodia
Venture Strategies for Health and Development Berkeley, CA USA
Improving health in rural Chinese villages using antibacterial mouth rinse

China is a lower-middle income country, with a population of 1.34 billion. Among this enormous population, there is dramatic disparity of maternal and neonatal health, with the rate of preterm low birth weight (PLBW) ranging from 5~6% in the developed metropolises to >20% in the poor rural areas. One possible reason for the high PLBW rate is poor maternal oral health, which adversely impacts the birth outcome.

Improving health in rural Chinese villages using antibacterial mouth rinse
Case Western Reserve University Cleveland, OH USA
Anti-retroviral Pouch for PMTCT During Home Birth

The transmission of HIV from mother to child during the birthing process can be largely prevented by the administration of anti­retroviral drugs. But, the child must receive the medication within 24 hours after birth to be effective. In Sub-Saharan Africa many clinics have the drug but most mothers deliver at home without it. Conventional containers, such as syringes, cups and pill bottles destroy the active ingredient in the medication. This means that the only way for most African children to receive medication is for the mother to travel to a clinic immediately after birth.

Anti-retroviral Pouch for PMTCT During Home Birth
Duke University Durham, NC USA
Plastic bags to increase skin-to-skin care and thermoregulation in low birth weight and preterm infants

Hypothermia is a serious risk for increased morbidity and mortality in newborn infants, especially low birth weight and preterm. In developed countries, expensive incubators and radiant warmers have effectively reduced hypothermia in newborns. However, in developing countries, inexpensive alternative approaches of skin-to-skin care is under-utilized. An innovative, low-cost solution to increase skin-to-skin care and prevent hypothermia is necessary for low- and middle-income countries.

Plastic bags to increase skin-to-skin care and thermoregulation in low birth weight and preterm infants
University Teaching Hospital Lusaka, Zambia
Pneumatic anti-shock garments for obstetric hemorrhage in an integrated healthcare system

Obstetric hemorrhage remains a major cause of death and disability for young women in low resource areas, particularly those from isolated rural areas. Most hemorrhage is postpartum and due to failure of the uterus to respond to hormonal stimulation. However, not all hemorrhage is due to atony and not all atonic uteruses respond to medications. Pneumatic anti-shock garments (PASG) have the potential to minimize blood loss, complications, and mortality from obstetric hemorrhage due to any etiology.

Pneumatic anti-shock garments for obstetric hemorrhage in an integrated healthcare system
Department of Emergency Medicine, University of New Mexico Albuquerque, NM, USA
Scaling up Every Second Matters for Mothers and Babies - KetamineTM (ESM-KetamineTM)

Maternal and newborn death and disability due to obstructed labor and lack of access to manual vacuum aspiration and tubal ligation can be reduced with increased availability of surgical services. We propose to scale-up a best-evidence package on the use of ketamine anesthesia for emergency cesarean section, tubal ligation, and other painful reproductive procedures in Kenya (called Every Second Matters for Mothers and Babies - KetamineTM) (ESM-Ketamine).

Scaling up Every Second Matters for Mothers and Babies - KetamineTM (ESM-KetamineTM)
Massachusetts General Hospital Boston, MA, USA
Making Births Safer through Mobile Banking Services (MBS2)

Scaled up and focused efforts to reduce maternal and neonatal deaths are urgently needed in the Philippines. Our team will utilize SMS through cell phones and mobile-based branchless banking to target women and families with critical health information and referrals, and to promote financial preparedness and savings for facility-based births. Building on BanKO's ongoing client expansion among low-income groups in rural areas, this initiative links mobile banking services and platforms with health promotion to save lives of vulnerable mothers and newborns.

Making Births Safer through Mobile Banking Services (MBS2)
Center for Health Solutions and Innovations Philippines, Inc. Makati City, Philippines
Scaling up an integrated intervention package

Deaths from PPH, eclampsia, infection and obstructed labour are the major obstacles in achieving MDG5; and infection, birth asphyxia and low-birth weight are for MDG4 in resource poor countries in Asia and Africa. These deaths are preventable, but, treatments along with functional health system are not always available and accessible in these countries. However, low-cost evidence-based solutions implementable at community level are available to prevent mortality from these causes.

Scaling up an integrated intervention package
International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) Dhaka, Bangladesh
Innovating with ultrasound to improve demand for skilled maternity care in Kenya

Jacaranda Health has a dual mission of providing affordable, high quality maternity services to low-income women whilst being a laboratory for integrating innovations for maternal health. We are a chain of maternity clinics in Kenya that provide deliveries, antenatal and postnatal care, and family planning.

Innovating with ultrasound to improve demand for skilled maternity care in Kenya
Jacaranda Health Nairobi, Kenya
Mama Co-op

Women in rural areas lack access to affordable, quality health prevention and treatment services. The absence of health treatment and prevention strategies partnered with harmful local customs discourages positive health outcomes. HealthPartners community-owned, sustainable health coop model empowers local stakeholders to partner for increased access to care and improved health outcomes. This is critical for reducing barriers for pregnant women to seek antenatal care, delivery with a skilled health professional and to receive critical follow up care immediately after birth.

Mama Co-op
HealthPartners Bloomington, MN USA
Strong answer to a tough problem: Making Maternity Waiting Homes more effective to save lives of mothers and babies in Afghanistan through innovative approaches

The provinces of Badakshan and Bamyan have among the highest maternal mortality in the world due to harsh geographic and weather conditions and difficult access to health facilities. The Aga Khan Health Service, Afghanistan (AKHS,A) has introduced Maternity Waiting Homes (MWH) in some facilities to encourage mothers with high-risk pregnancies to stay in these facilities for 2-3 weeks before and after delivery to ensure supervised labor and better neonatal care. AKHS,A, along with other partners, is already running telehealth services in these provinces.

Strong answer to a tough problem: Making Maternity Waiting Homes more effective to save lives of mothers and babies in Afghanistan through innovative approaches
Aga Khan Health Services, Afghanistan Kabul, Afghanistan
SafeSnip: cuts, clamps, and shields umbilical cords from infection

NOvate Medical Technologies, LLC (“NOvate”) is a New Orleans-based medical device development company focused on commercializing high-quality, low-cost medical products.  NOvate is committed to delivering medical solutions, novel training programs, and information technologies which address the health needs of the developing world.  NOvateâs first product offering, SafeSnip, is a patent-pending disposable and degradable plastic obstetric device that simultaneously cuts, clamps, and shields the umbilical cord from infection.

SafeSnip: cuts, clamps, and shields umbilical cords from infection
NOvate Medical Technologies, LLC New Orleans, LA USA
Co-administration of influenza and tetanus toxoid vaccines to pregnant mothers using a simple-to administer, thermostable microneedle patch that generates no sharps waste

Reduction of maternal and neonatal death rates in developing countries is far behind the Millennium Development Goals. One method the WHO has recommended to bring down these rates is antenatal vaccination against two life threatening diseases- influenza and tetanus. Unfortunately many countries face bottlenecks for these vaccines because of a shortage  in trained health care personnel, and the need for syringes and needles for administration as well as refrigeration for storage.

Co-administration of influenza and tetanus toxoid vaccines to pregnant mothers using a simple-to administer, thermostable microneedle patch that generates no sharps waste
Emory University Atlanta, GA, USA
Lean Maternity: Optimizing the management of Obstetric and Neonatal Emergencies in Low-Resource Settings

Stock-outs, misuse and misappropriations of essential drugs and supplies are leading contributors to facility-based maternal and newborn mortality. Worldwide facility-based mortalities account for 40-90% of all maternal deaths. In western Kenya, one third of all mortalities take place in hospitals, and less than 15% of facilities are equipped to perform basic Emergency Obstetric and Newborn functions. Without supplies always available and within reach and without providers ready to react and act, deaths from hemorrhage, eclampsia and maternal/newborn sepsis remain unacceptably high.

Lean Maternity: Optimizing the management of Obstetric and Neonatal Emergencies in Low-Resource Settings
Moi University Eldoret, Rift Valley, Kenya
Exploring the Demand and Supply Dynamics of 4% Chlorhexidine in Madagascar

Neonatal infections are estimated to account for over one million newborn deaths annually, almost half of which happen in Africa. Community-based trials in Asia applying a 4% chlorhexidine (4% CHX) to the umbilical cord showed reduction in newborn death by 23% and a three-quarters reduction in serious umbilical infections. Effectiveness trials to generate evidence in Africa are underway in Tanzania and Zambia and are expected to be completed in 2014.

Exploring the Demand and Supply Dynamics of 4% Chlorhexidine in Madagascar
Population Services International Washington, DC USA
An intuitive multi-use intrauterine device (IUD) inserter to expand access to contraceptives and family planning in resource poor settings

Two hundred and twenty million women worldwide have an unmet need for family planning resources. Although intrauterine devices (IUDs) are effective long-acting contraceptives, IUD insertion is very complex, so IUDs are often unavailable in resource poor settings. Bioceptive's proposal is to create a reusable IUD inserter for the developing world with the goals that it is intuitive, Cu380A IUD compatible, safer, and low cost.

An intuitive multi-use intrauterine device (IUD) inserter to expand access to contraceptives and family planning in resource poor settings
Bioceptive, Inc. New Orleans, LA, USA
Delayed cord clamping for the new-born in need of neonatal resuscitation

Robust evidence shows that delayed cord clamping (DCC) of a vigorous child after birth is superior for neonatal health compared to early clamping. The benefit in low-income settings is even more evident given the limited resources available for postpartum care. DCC will allow for a prolonged transfusion of blood from mother to child resulting in a lower rate of neonatal anemia, serious neonatal infection, and brain hemorrhage, and also a better iron supply during early infancy.

Delayed cord clamping for the new-born in need of neonatal resuscitation
Patan Academy of Health Sciences, Uppsala University Lalitpur, Nepal and Uppsala, Sweden
Performance of an innovative, instrument-free, low-cost, rapid point-of-care CD4 test for accelerating initiation of antiretroviral interventions for HIV 1-infected pregnant women in resource-constrained settings

HIV infection accounts for 9% of deaths of pregnant women in sub-Saharan Africa (42.5% in South Africa) and substantially hinders progress towards reducing maternal mortality. HIV infection during pregnancy also contributes to poor perinatal health outcomes (stillbirth, preterm birth, low birth weight, HIV infection). Poor uptake and delayed initiation of antiretroviral interventions are the principal determinants of HIV infection of infants and HIV-related maternal deaths.

Performance of an innovative, instrument-free, low-cost, rapid point-of-care CD4 test for accelerating initiation of antiretroviral interventions for HIV 1-infected pregnant women in resource-constrained settings
Burnet Institute Melbourne, Australia
Postpartum empowerment: an integrated approach driving demand and delivery of high quality, low-cost postnatal services in Kenya

Jacaranda Health has a dual mission of providing affordable, high quality maternity services to low-income women whilst being a laboratory for integrating innovations for maternal health. We are a chain of maternity clinics in Kenya that provide deliveries, antenatal and postnatal care, and family planning.

Postpartum empowerment: an integrated approach driving demand and delivery of high quality, low-cost postnatal services in Kenya
Jacaranda Health Nairobi, Kenya
Brilliance and Comet: Integrated Innovation to Effectively Treat Severe Neonatal Jaundice

Approximately 12 percent of babies born in low-income countries require immediate treatment for severe jaundice. Without timely treatment, they may suffer brain damage or die. Effective treatment simply does not exist in rural clinics and a vast majority (95%) of public hospitals in low-income countries.

Brilliance and Comet: Integrated Innovation to Effectively Treat Severe Neonatal Jaundice
D-Rev: Design for the Other Ninety Percent Palo Alto, CA USA
Improved hygiene at birth with Byotrol, an innovative sanitizer and disinfectant

Does hand washing with soap and water or alcohol-based hand sanitizers address the well-documented need for clean birth practices? Clean birth practices, including hand hygiene of birth attendants and use of clean or disinfected instruments to cut and tie an umbilical cord, are of critical importance. Evidence suggests that hand hygiene practices among birth attendants and disinfection of birthing equipment and surfaces are not always optimal. Often water and soap or alcohol-based hand rubs are not available.

Improved hygiene at birth with Byotrol, an innovative sanitizer and disinfectant
Program for Appropriate Technology in Health (PATH) Seattle, WA USA
A Sanitary Kit for Traditional Midwives

In rural Kenyan communities, freelance birth attendants are often called upon to attend to a "home delivery."  Basic issues like a general lack of sterility and hygiene instruments (clean water and a disinfected environment) greatly compromise infection control in such settings making home deliveries truly high-risk processes. Indeed, there have been increasing reports of poor handling of umbilical cord and subsequent infant infections due to use of poorly chosen instruments during delivery.

A Sanitary Kit for Traditional Midwives
University of Nairobi Nairobi, Kenya
Uniting local stakeholders for multi-level intervention in the Democratic Republic of Congo

This consortium will test a set of empowerment innovations for pregnant women through Safe Motherhood Solidarity Groups on Idjwi Island in Democratic Republic of Congo focusing on three strategic interventions: 1) Providing women with financial autonomy through the creation of community insurance programs that will enable access to all needed services for mothers and newborns in health centers, 2) enabling communities to actively design feasible, home-based maternal and neonatal assessment tools to monitor outcomes through the implementation of a participatory communication model, and 3) tr

Uniting local stakeholders for multi-level intervention in the Democratic Republic of Congo
Eastern Congo Initiative (A Project of New Venture Fund) Washington, DC USA
Augmented Infant Resuscitator (AIR)

Globally 814,000 neonatal deaths result from intrapartum birth asphyxia in term babies and 1.03 million from complications of prematurity (WHO/ UNICEF 2010). Effective resuscitation could reduce intrapartum related neonatal deaths by 30%, and deaths from prematurity by 10%, creating potential to save 347,200 babies annually. However, one in five trained healthcare professionals (HCPs) fail to perform the resuscitation technique correctly, and those that do, often experience a rapid decline in proficiency (Patel J et al 2012).

Augmented Infant Resuscitator (AIR)
Mbarara University of Science and Technology Mbarara, Uganda
Husbands as Partners Campaign: Championing Men as Partners in Reducing Maternal and Neonatal Mortality in Senegal

Most life-threatening obstetric complications occur during labor and delivery. The "three delays model" identifies three delays that contribute to maternal and newborn mortality when emergencies occur during childbirth: delay in deciding to seek care, in reaching a care facility, and in actually receiving care. Women's access to antenatal care and trained care at birth, including emergency obstetric and neonatal care, is proven to significantly reduce maternal and neonatal mortality.

Husbands as Partners Campaign: Championing Men as Partners in Reducing Maternal and Neonatal Mortality in Senegal
Farm Radio International Ottawa, Canada
Low-cost Incubator and Ventilator for Saving Lives at Birth

Low-resource environments present many challenges for maternal and neonatal healthcare delivery. Among these, is a lack of basic equipment to preserve and protect newborns, particularly at-risk neonates. For example, a simple incubator/warmer is lacking in most primary health care facilities. Devices to provide respiratory support are also lacking. Furthermore, available solutions pioneered by developed countries do not fare well in a resource limited area- for example, reliable electricity supply is not readily available.

Low-cost Incubator and Ventilator for Saving Lives at Birth
University of Maryland Baltimore County Baltimore, MD, USA
Sustainable Access to Maternal/Newborn Services: A Market Approach

Over 24 months with $250,000 in seed funding Partners for Development (PFD) will develop an innovative model to ensure access to ante/postnatal and delivery care (ANC/PNC) in 25 underserved villages in northeastern Cambodia: a transportation system of private sector providers in partnership with local government. To increase demand for such transport and make the system financially sustainable, routes will include schools, markets and other popular destinations in addition to health facilities.

Sustainable Access to Maternal/Newborn Services: A Market Approach
Partners for Development Silver Spring, MD USA
Innovative mHealth Approach to Improving the Quality of Maternal and Newborn Care in Tanzanias Private Sector Drug Shops

Poor access to quality maternal, newborn, and family planning services contribute to high maternal and neonatal mortality rates in Tanzania, particularly in hard-to-reach areas. In order to enhance access, Tanzania’s accredited drug dispensing outlets (ADDOs), which are often the first stop for health care, especially for rural women, must be better prepared to provide such lifesaving services. We propose validating an innovative model that combines enhanced training with mobile phone decision-support tools.

Innovative mHealth Approach to Improving the Quality of Maternal and Newborn Care in Tanzanias Private Sector Drug Shops
Management Sciences for Health Arlington, VA, USA
BreathAlert: High-Performance, Low-Cost Method to Reduce Death Due to Apnea of Prematurity

Rationale: During the first days of life, premature infants are at high risk of apnea – wherein they suddenly stop breathing. Fortunately, apnea is easily treated by simple tactile stimulation. In high resource settings, electronic monitors detect apnea; alarms alert nurses to intervene until breathing resumes. As the baby grows, apnea of prematurity is self-resolving. Unfortunately, existing monitors are too expensive for low-resource settings; instead, nurses visually monitor babies.

BreathAlert: High-Performance, Low-Cost Method to Reduce Death Due to Apnea of Prematurity
William Marsh Rice University Houston, TX, USA
Reducing neonatal mortality through administration of BCG soon after birth - a cluster randomised trial of improved service delivery

Rationale: Newborns are vulnerable and have high mortality in low income countries. BCG vaccine is known to stimulate the immune system and its early administration can modulate how the child copes with other infections. In randomised trials of BCG-at-birth to low-birth-weight (LBW) children, we have shown that BCG is associated with 40-50% lower neonatal mortality, the effect being due to less neonatal sepsis and respiratory infections. The beneficial effect has been observed already within the first three days.

Reducing neonatal mortality through administration of BCG soon after birth - a cluster randomised trial of improved service delivery
Projecto Saude Bandim Bissau, Guinea-Bissau
Low-cost salivary progesterone testing for detecting the risk of preterm births in rural community settings of India

India faces the daunting task of saving 3.6 million preterm babies annually. Early identification of pregnant women at risk of premature delivery could significantly reduce the number of preterm births, deaths and the disability burden. The project proposes to assess the validity and feasibility of an innovative, cost effective and non-invasive salivary progesterone test to predict preterm births among pregnant women in two rural districts of Madhya Pradesh, India, which have higher rates of prematurity and limited access to quality antenatal care and healthcare facilities.

Low-cost salivary progesterone testing for detecting the risk of preterm births in rural community settings of India
MAMTA Health Institute for Mother and Child New Delhi, India
Scaling CommCare Innovations for Better Community Health to Millions

In order to help save newborn lives across the globe, we propose three major objectives: (1) Integration of past and future innovations through development of a CommCare "App Store", (2) Scaling CommCare through building of mHealth capacity in 75 new partners over 3 years; (3) Evaluation of CommCare's impact on saving newborn lives in two large-scale controlled studies.

Scaling CommCare Innovations for Better Community Health to Millions
Dimagi, Inc. Cambridge, MA USA
m-CTG: A low cost mobile-phone cardiotocograph device for antenatal and intrapartum monitoring to prevent perinatal mortality in low resource settings

Still birth and birth hypoxia remain challenge for many developing countries including India. Appropriate monitoring is important to detect the at-risk mothers and fetuses for complicated labour, fetal distress, birth hypoxia, still birth and neonatal death. Cardiotocography (CTG) is widely used for monitoring in later pregnancy and during labor to detect at-risk mothers and fetuses. CTG device or Doppler FHR monitor is not available at most of the public health facilities in India.

m-CTG: A low cost mobile-phone cardiotocograph device for antenatal and intrapartum monitoring to prevent perinatal mortality in low resource settings
The INCLEN Trust International New Delhi, India
Addressing the Fourth Delay: Improving community-based accountability for MNH

We seek to address a critical fourth delay that sustains high rates of maternal and neonatal mortality in western Kenya: the delay in a community’s accountability to its mothers and infants. We will develop an innovative information technology that fosters rapid communication and feedback between mothers, their communities, and their healthcare providers: the Mother-Baby Health Network.

Addressing the Fourth Delay: Improving community-based accountability for MNH
Moi University School of Medicine Eldoret, Kenya
Integrated Management of Pregnancy and Childbirth in Tanzania

The intrapartum period represents a time of high risk for women and newborns in Tanzania. Our project focuses on increasing utilization of high quality, evidence based care provided by midwives in the rural Lakes Region of Western Tanzania in alignment with the Ministry of Health and Social Welfare's (MoHSW) Road Map Strategic Plan to Accelerate the Reduction of Maternal, Newborn and Child Deaths.

Integrated Management of Pregnancy and Childbirth in Tanzania
New York University (NYU) New York, NY USA
Reducing Maternal and Perinatal Mortality in Ghana by Improving Service Delivery Capacity: Introducing Systematic Quality Improvement Methodologies into the Greater Accra Health Region.

This project expands a 5 year Kybele-Ghana Health Service partnership analyzing systems and patient care processes at Ridge Hospital, a large obstetric referral center in Accra. The partnership addressed leadership, motivation, knowledge deficits, equipment shortage, patient flow and communication problems yielding a 34% decrease in maternal mortality and a 36% decrease in stillbirth, despite a 36% increase in patient admission with higher disease acuity.

Reducing Maternal and Perinatal Mortality in Ghana by Improving Service Delivery Capacity: Introducing Systematic Quality Improvement Methodologies into the Greater Accra Health Region.
Kybele, Inc. Winston-Salem, NC USA
Establishment of a novel Community Birth Attendants (CBA) Academy embedded with mobilemoney solutions for safer deliveries in Imo State, Nigeria

The problem is lack of skilled/equipped Traditional Birth Attendants(TBAs) with financial resources to provide quality care during birth in hard-to-reach communities in Imo State Nigeria. TBAs are unskilled and their maternity homes lack electricity, clean water and proper equipment to conduct evidence based practices. TBAs are usually unbanked, financially excluded which limits their access to credit.

Establishment of a novel Community Birth Attendants (CBA) Academy embedded with mobilemoney solutions for safer deliveries in Imo State, Nigeria
Widows and Orphans Empowerment Organization (WEWE) Abuja, Nigeria
Adapt: Empowering and equipping health workers to manage PPH safely and confidently

Postpartum hemorrhage (PPH) remains the leading cause of maternal mortality and morbidity worldwide, representing one out of every four maternal deaths that occur annually. The tamponade-approach has proven 80-90% effective in PPH management, and can decrease the need for referral and advanced surgical care, as well as preserve the reproductive capacity of young women who experience PPH.

Adapt: Empowering and equipping health workers to manage PPH safely and confidently
Jhpiego Corporation Baltimore, MD, USA
DOMANO (Donor Management Online)

Haemorrhage accounts for up to a third of maternal deaths; safe blood is too often unavailable. As the letter of support from the CEO of one partner, the National Blood Service of Zimbabwe (NBSZ), notes: "As 40% of all blood supplies are given to mothers, shortage of blood seriously contributes to maternal mortality."

DOMANO (Donor Management Online)
Global Blood Fund Oklahoma City, OK USA
Preventing Hemorrhage Saving Lives: Tapping the Power of Narrative

We propose a simple, flexible multimedia intervention delivered via social networks to empower a rural Nigerian community to learn about and gain access to an inexpensive lifesaving intervention for the prevention of postpartum hemorrhage: misoprostol. We will create a “simple illustrated video”, an illustrated story with narrative and music, to be delivered and shared by mobile phone or via a laminated "flipbook" based on the documentary The Edge of Joy which tells the story of postpartum hemorrhage from the perspective of Nigerian women, men and healthcare providers.

Preventing Hemorrhage Saving Lives: Tapping the Power of Narrative
The University of Chicago Chicago, IL USA
Simple Diagnostic Device for Early Detection of Neonatal Sepsis

Neonatal mortality in developing countries averages about 34 per 1000 live births and the most common cause of death is bacterial infection. Neonatal sepsis contribute to 34.6% of all early onset infections and causes about 1.6 millions deaths a year. Sepsis mortality is directly related to the severity of stage at which it is diagnosed. Therefore, it is widely accepted that the effective treatment of neonatal sepsis requires early detection and rapid therapeutic intervention.

Simple Diagnostic Device for Early Detection of Neonatal Sepsis
Lucerna, Inc. New York, NY USA
Islamic Opinion Leaders: Building capacity for maternal, neonatal and child health in Northern Nigeria

The problem identified is the low uptake of MNCH services in Muslim communities in Northern Nigeria (NDHS 2008 and 2013). Misinformation and mis-perceptions preached by Islamic scholars on Islamic precepts on family planning, child-spacing, breastfeeding, immunization and child rearing practices contribute to this situation. In our previous SLaB project the dRPC identified 14 Islamic scholars and 28 apprentices who preached against MNCH interventions and transformed them into champions for correct messages and practices.

Islamic Opinion Leaders: Building capacity for maternal, neonatal and child health in Northern Nigeria
development Research and Projects Centre Kano City, Kano, Nigeria
Validation and Introduction of a Low-Cost Bubble Continuous Positive Airway Pressure Kit and Oxygen Blender for Neonates

Respiratory distress syndrome affects roughly 1 million neonates each year and is almost always fatal without effective treatment. Continuous positive airway pressure (CPAP) therapy is the standard of care for treatment of neonatal respiratory distress, but the availability of CPAP devices is limited by cost and facility infrastructure such as electricity and pressurized air. The bubble CPAP (bCPAP) kit and oxygen blender address the lack of electricity and pressurized air, common in rural health clinics, and have been demonstrated to provide a stable supply of blended gas.

Validation and Introduction of a Low-Cost Bubble Continuous Positive Airway Pressure Kit and Oxygen Blender for Neonates
PATH Seattle, WA, USA
Mapping High Risk Pregnancies with Essential Diagnostic Kit in Remote and Vulnerable Populations in Afghanistan

This 24 month project integrates innovative uses of technology with women’s on-the-doorstep personalized pregnancy diagnostic services and raises awareness of the need to obtain antenatal care, particularly in remote and nomad Kuchi populations, in Herat Province, Afghanistan. The project is staffed by women doctors, midwives and community health workers (CHWs) who work together across traditional boundaries to save women’s lives in pregnancy and childbirth.

Mapping High Risk Pregnancies with Essential Diagnostic Kit in Remote and Vulnerable Populations in Afghanistan
Associazione Italiana Solidarietà tra i Popoli (AISPO) Milan, Italy
Development and Application of a Point-of-Care Assay for Plasma Bilirubin

Devastating brain injury and neonatal death caused by hyperbilirubinemia (kernicterus) is very common in low resource settings (LRS) but can be prevented by early detection and treatment with light therapy. A major roadblock to the global effort to eliminate kernicterus is the inability to measure total plasma bilirubin (TB) in most LRS, including many referral hospital centers. To meet this need, we are developing an inexpensive POC system that rapidly measures TB. A small drop of blood (ca.

Development and Application of a Point-of-Care Assay for Plasma Bilirubin
BILIMETRIX SRL Trieste, Italy
Can lactoferrin correct iron deficiency in pregnancy more effectively than iron supplements to prevent low birthweight, preterm birth and potentially improve neonatal survival?

Lactoferrin, a safe, naturally occurring iron-binding protein found in high concentration in breast milk, offers an exciting new approach to correct iron deficiency early in pregnancy, prevent low birth weight, preterm delivery and reduce neonatal deaths. It has few side effects, facilitates absorption of iron, and reduces maternal inflammation to enhance the utilization of iron giving it the potential to rapidly restore iron status in pregnant women, even in populations with high burdens of infectious diseases.

Can lactoferrin correct iron deficiency in pregnancy more effectively than iron supplements to prevent low birthweight, preterm birth and potentially improve neonatal survival?
The University of Sydney Sydney, Australia
Improving birth outcomes through enhanced targeting of nutrition interventions to mothers and children during the 1000 days from pregnancy to age two through use of biometric technology

Under-nutrition is the underlying cause of 3.5 million preventable maternal and child deaths each year. JSI is developing innovative technology to support the delivery of nutrition actions at critical times in the life-cycle of women, infants and young children, especially during the 1,000 days between a woman's pregnancy and her child's second birthday.

Improving birth outcomes through enhanced targeting of nutrition interventions to mothers and children during the 1000 days from pregnancy to age two through use of biometric technology
JSI Research and Training Institute, Inc. Arlington, VA USA
Development of a reectal antibiotic formulation for community based management of neonatal sepsis

Rationale: Deaths from neonatal sepsis are avoidable. Most occur at home in areas where home delivery rates are high and unhygienic conditions are common. When a newborn has sepsis, death can occur within hours, but parents often refuse to proceed to a hospital and have the child admitted even if transport is provided. A 2007 Consultation of Saving Newborn Lives recommended a simpler regimen that could enable initiation of management (or complete management) closer to the home and increase family acceptance of treatment.

Development of a reectal antibiotic formulation for community based management of neonatal sepsis
University of Oxford Oxford, UK
Scaling proven mobile maternal health e-vouchers in Western Kenya

Our plan is to scale up a proven, innovative e-voucher-which covers the costs of maternity care and transportation to clinics-with the addition of SMS reminders. Together they can reduce financial and informational barriers to care and dramatically increase skilled facility-based deliveries in rural Kenya. We will further innovate and test ways to overcome cultural and gender-based constraints to maternal health care by sending financial incentives to traditional birth attendants and SMSs to husbands to motivate them to encourage women to deliver in facilities.

Scaling proven mobile maternal health e-vouchers in Western Kenya
Changamka Microhealth Limited Nairobi, Kenya
A novel clinical tool to predict cephalopelvic disproportion (CPD), the leading mechanism of obstructed labor

Cephalopelvic disproportion (CPD) is the primary mechanism of obstructed labor, one of the five major causes of maternal mortality globally. A term literally translating to the mismatch between the fetal skull and woman's pelvis, this condition is most felt by women who, because of poor nutrition, young age of motherhood, and/or bone-affecting disease, have an improperly developed pelvis that is unsuitable for childbirth.

A novel clinical tool to predict cephalopelvic disproportion (CPD), the leading mechanism of obstructed labor
University of California, San Francisco San Francisco, CA USA
Efficacy and Cost-Effectiveness of a Culturally Appropriate Iron Fortified Food for Pregnant Women in India

Iron deficiency anemia affects 42% of all pregnant women across the globe, and contributes to 20% of all maternal deaths and low birth weight and pre-term births. Studies show improving hemoglobin by 1gm/L results in a 25% reduction in maternal morbidity. Taking iron pills daily is the status quo solution for addressing maternal anemia, but the average adherence is abysmally low (particularly in low-resource settings) and efforts to reduce anemia have stalled. In India the average adherence for women with iron pills is just 35%.

Efficacy and Cost-Effectiveness of a Culturally Appropriate Iron Fortified Food for Pregnant Women in India
Violet Health Inc New York, NY, USA
Maternity Waiting Homes: Integrated Maternal and Child Health

Africare is proposing to scale up an integrated package of maternal and newborn care interventions to increase demand for and access to quality services at birth. Targeted follow up by safe motherhood action group (SMAG) volunteers is facilitated by the use of an electronic tracking tool (CommCare) at health centers. The SMAG volunteers will provide linkages to other services such MWHs and motorbike ambulance to reduce barriers to access. The project will reach approximately 11,691 pregnant women in Kasama and Mpika Districts annually for three years with the integrated interventions.

Maternity Waiting Homes: Integrated Maternal and Child Health
Africare Washington, DC, USA
Towards infant AIDS cures through early combination antiretroviral therapy (cART): investigating novel diagnostics.

The first well-documented case of a probable HIV-1 cure by early infant combination antiretroviral therapy (cART), initiated within hours after birth, has recently been publicized. Recent evidence also suggests that very early cART would improve prognosis, even when cure is not achieved. Diagnosis of HIV-1 within 48h of birth indicates intra-uterine infection, which most often occurs in the days preceding delivery, thus offering a unique opportunity to treat HIV-1 at a very early stage. A highly sensitive point-of-care assay would facilitate diagnosis in a busy labor ward setting.

Towards infant AIDS cures through early combination antiretroviral therapy (cART): investigating novel diagnostics.
Stellenbosch University Cape Town, South Africa
Scaling up mHealth in the Guatemalan Highlands to reduce maternal and new-born mortality

The project will be addressing the scaling up an mHealth program to reduce maternal and neonatal mortality in rural hard to reach indigenous communities of northern Guatemala. The Tula Foundation has been working with the Ministry of Health & Public Assistance since 2004 to train culturally appropriate community auxiliary nurses and other health professionals.

Scaling up mHealth in the Guatemalan Highlands to reduce maternal and new-born mortality
Tula Foundation Heriot Bay, BC Canada
Increasing healthy behaviors and use of reproductive health services through improved quality of care, novel incentives, information technology, and enhanced demand for health products

In Nyanza Province, Kenya, there are nearly 5 maternal deaths and 39 neonatal deaths for every 1000 live births. These high mortality rates largely stem from little and low-quality health care, endemic malaria, lack of safe water, sanitation and hygiene, and deep poverty. Such problems arise in part because of underdeveloped systems to distribute information, goods and services to poor rural women. We propose a comprehensive integrated program to address the comprehensive interrelated factors leading to poor maternal and child health.

Increasing healthy behaviors and use of reproductive health services through improved quality of care, novel incentives, information technology, and enhanced demand for health products
RAND Corporation Santa Monica, CA USA
Male Fertility Preferences and Maternal Mortality

The project aims to address the consequences of male fertility preferences when men are uninformed about of the health risks associated with pregnancy and childbirth, namely low uptake of available family planning and low understanding of the benefits of birth spacing. In order to inform men of these risks, an innovative curriculum has been designed over one year of piloting that introduces family planning as a way to mitigate potential maternal and child mortality.

Male Fertility Preferences and Maternal Mortality
Innovations for Poverty Action (IPA) New Haven, CT USA
Low cost, needle-free and non-refrigerated treatment for PPH

Drugs are available to prevent bleeding after giving birth (postpartum haemorrhage). However, current products are poorly suited to transportation, storage or administration in resource-poor countries. The drug of choice for treatment of postpartum haemorrhage is oxytocin, which is given via injection. This presents complications in developing countries, where it is often not possible to provide sterile equipment, clean water or trained medical personnel during childbirth.

Low cost, needle-free and non-refrigerated treatment for PPH
Monash University Clayton, Australia
Roshini - Play to Live

We propose developing and testing an interactive mobile game designed to extend and augment the current neonatal and postnatal information delivered by accredited social health activists and learning groups to pregnant and new mothers in three rural locations in Uttar Pradesh, India. The game will build on an existing short message service quiz game using an engine technology developed by Ayogo Health Inc., a serious games company based in Vancouver, BC, and will incorporate content developed under PATH's work with mothers groups in India.

Roshini - Play to Live
Program for Appropriate Technology in Health (PATH) Seattle, WA, USA
Access Project: Community Use of Mobile Phones and Peer Microfinance Groups

URC and major providers of mobile phone services (TIGO, AIRTEL and VODACOM) will initiate a program whereby community volunteers will be provided with mobile phones and monthly credit of 20,000-TSH (15 USD) to enable subsidized text messages to Health facilities for anticipated difficult deliveries. All pregnant women at the time of their booking will be invited to be members of appropriate peer microfinance group by facility staff. HIV positive pregnant women will be linked to PLHIV groups for peer support during pregnancy.

Access Project: Community Use of Mobile Phones and Peer Microfinance Groups
University Research Co., LLC Bethesda, MD USA
SimPrints Biometric System for Health Workers

The perinatal period is fraught with risk for both mother and child in developing countries, accounting for over 70% of preventable maternal and infant deaths annually. The WHO recommends at least four antenatal visits with community health workers (CHW) to mitigate these risks. However achieving this continuity of care is difficult due to challenges in patient identification, access to health records, and visit verification.

SimPrints Biometric System for Health Workers
SimPrints Technology Ltd. Cambridge, Cambridgeshire, UK
Prevention of maternal death by improving iron status of women through iron fortification of tea

Iron deficiency is a major contributor to maternal death. Improving the health of women through iron fortification of a universally consumed food vehicle will result in significant saving of lives at birth. Tea is universally consumed in South Asia; however iron forms complexes in tea, reducing bioavailability, and thus thwarting earlier fortification attempts. Our approach will make tea viable as an iron fortification vehicle.

Prevention of maternal death by improving iron status of women through iron fortification of tea
University of Toronto Toronto, Ontario, Canada
Ultrasound4Africa

Optimal care during childbirth in rural areas of most low and middle income countries is hampered by 2 major problems: the limited equipment and capacity of health workers for diagnosis, and the quasi-absence of back-up from the hospital, which impacts on their motivation and competence. In order to improve the technical quality of care and the motivation of primary care maternity staff working in rural areas of low-income countries, the Ultrasound4Africa project proposes to develop a two-pronged integrated intervention:

Ultrasound4Africa
Institute of Tropical Medicine - Antwerp Antwerp, Belgium
CommTrack: A Distribution Management System to Serve the Last Mile

Urgent shortages of medicines in low-income countries lead to millions of unnecessary deaths at birth every year. One pervasive challenge causing such shortages is how to move the right commodities to the right place on time and at cost. We propose to develop an open-source distribution management system which leverages our existing real-time dataset of stock transactions at thousands of facilities in Africa to drive automated improvements in practice.

CommTrack: A Distribution Management System to Serve the Last Mile
Dimagi, Inc. Cambridge, MA, USA
Babies Breathing Better

Indoor air pollution from burning biomass fuels increases the risk of low birth weight, prematurity, and pneumonia. With ≈1% of the Zambian population having access to improved stoves, most pregnant women and neonates are unprotected from indoor air pollutants. Little effort is invested in identifying interventions to reduce exposure of pregnant women and neonates to fine particles and carbon monoxide.

Babies Breathing Better
The Research Foundation of the State University of New York Buffalo, NY, USA
Community-led evidence-based action for newborns (CLEAN) at scale through participatory women's groups (PWGs), health workers and clean delivery kits (CDKs): saving lives at birth in rural Bangladesh.

In poor communities, Participatory Women's Groups (PWGs) that focus on maternal and newborn health can dramatically reduce newborn deaths and catalyze improvements in the demand, delivery and quality of maternity services. Trials in Nepal, India, Malawi and Bangladesh showed that engaging PWGs in participatory learning and action reduced newborn deaths by up to one third. Coverage is important. In Bangladesh, with one group per 1500 population, newborn mortality fell by 7%; when scaled to 1 group in 300, mortality fell by 34%.

Community-led evidence-based action for newborns (CLEAN) at scale through participatory women's groups (PWGs), health workers and clean delivery kits (CDKs): saving lives at birth in rural Bangladesh.
University College London London, UK
Engineering Lactobacillus casei to Enable Sustainable Home Production of Vitamin A Enriched Dairy Foods by At-Risk Mothers

Vitamin A deficiency (VAD) is a major problem in the developing world that disproportionately affects pregnant women, children, and infants. Vitamin A's role in development and immunity make it critically important to natal/neonatal health. The use of supplements, crops, and grains to reduce VAD has been met with limited success due to issues such as dependency on suppliers, lack of cultural acceptance, high costs, distribution difficulties, and hypervitaminosis. A sustainable, culturally acceptable, and safe way of fighting VAD is needed, particularly in Southern Asia.

Engineering Lactobacillus casei to Enable Sustainable Home Production of Vitamin A Enriched Dairy Foods by At-Risk Mothers
The Board of Regents of the University of Wisconsin System Madison, WI, USA
Planning for scale-up of a noninvasive anemia screening and monitoring technology in low-resource settings

Anemia is one of the most serious global health problems, and it particularly affects pregnant women in developing countries. Anemia often goes undetected and untreated, placing women and their newborns at risk for poor pregnancy outcomes. Nowhere is this truer than in Africa where an estimated 200,000 women die from birth complications every year.

Planning for scale-up of a noninvasive anemia screening and monitoring technology in low-resource settings
Program for Appropriate Technology in Health (PATH) Seattle, WA USA
An Innovative Service Delivery Solution for Maternal and Neonatal Health in Burma

Burma is one of the poorest countries in Asia, and its per capita public investment in healthcare is amongst the lowest in the world. Burma's 55 million people rely heavily on unregulated private sector health services. Lack of access and prohibitive service costs preclude poor women and their children from accessing basic health services. Burma urgently needs cost-effective, scalable solutions to provide the continuum of care needed to reduce maternal and neonatal mortality.

An Innovative Service Delivery Solution for Maternal and Neonatal Health in Burma
Population Services International Washington, DC USA
Bullseye: Smartphone-Based Maintenance of Phototherapy Equipment for Neonatal Jaundice

Rationale: Severe neonatal jaundice (hyperbilirubinemia) can be treated by exposing an affected newborn to intense blue light. However, babies diagnosed with jaundice are often placed under phototherapy lights that are ineffective, old or poorly maintained. Inexpensive solutions for predictive maintenance of such technologies are needed to assess the quality of treatment and provide data for long-term equipment management.

Bullseye: Smartphone-Based Maintenance of Phototherapy Equipment for Neonatal Jaundice
Nexleaf Analytics Los Angeles, CA USA
A simple tool and mobile phone application to improve community-based case management of premature and jaundiced newborns

We aim to develop and validate simple, low-cost, low-technology tools to improve community-based identification, referral, and care of premature and jaundiced newborns by frontline health workers. In our current seed grant, we designed a simple prematurity scorecard for community health workers (CHWs) to assess for prematurity, developed a training program, and will soon complete a validation study enrolling 1,000 pregnancies in Sylhet, Bangladesh. CHWs conducted the maturity assessment with high levels of agreement with physicians.

A simple tool and mobile phone application to improve community-based case management of premature and jaundiced newborns
The Brigham and Women's Hospital Boston, MA, USA
Improving Health Service Delivery Through Community Monitoring and Non-Financial Awards

Maternal and child health in poor countries suffers from failures in supply and demand. Health workers face weak incentives to provide quality services, while patients under-utilize what health services do exist, due to cost, lack of information, and perceived low quality of services. We propose to conduct an investigation of two innovative, social accountability interventions that aim to address these shortcomings by incentivizing health workers and stimulating demand for health services.

Improving Health Service Delivery Through Community Monitoring and Non-Financial Awards
Innovations for Poverty Action (IPA) New Haven, CT USA
Conditional Cash Transfer Scheme (CCTS) Zambia

This proposal outlines a model for demonstrating whether a Conditional Cash Transfer Scheme (CCTS), integrated into a larger program effort, can increase demand for and utilization of maternal and neonatal health (MNH) services in rural Zambia, where health indicators remain stubbornly dire. The model is based on evidence suggesting that current demand-side interventions, including increasing knowledge of danger signs and raising awareness of available services will not be sufficient to overcome the barriers necessary to bring utilization in line with clinical need.

Conditional Cash Transfer Scheme (CCTS) Zambia
Health Partners International Ltd. Lewes, East Sussex UK
GUHUZA -Connecting mothers to health care through group SMS and ambulance services

In Rwanda, lack of access to health care, especially for rural communities, is reflected in high maternal mortality rates; 540 out of every 100,000 live births lead to a mother's death. The infant mortality rate is even higher - for every 1,000 births, 27 do not survive. Almost 37% of mothers deliver at home and only 35% of mothers attend appropriate antenatal care visits at clinics. To address this, ADRA will implement the GUHUZA project, to "connect" mothers to health care.

GUHUZA -Connecting mothers to health care through group SMS and ambulance services
Adventist Development and Relief Agency (ADRA), International Silver Spring, MD USA
Sublingual, heat-stable oxytocin tablets for postpartum hemorrhage: A simple, rapid, needle-free approach

Postpartum hemorrhage (PPH) is the most significant contributor to maternal mortality and morbidity worldwide, disproportionately affecting women in low-resource settings. Most women in these settings deliver without skilled birth attendants, hours away from facilities where skilled birth attendants are available. Injectable oxytocin has been recommended by the World Health Organization for routine use in prevention and treatment of PPH. However, safely delivering an injection requires a trained provider and sterile equipment, ideally in a health facility setting.

Sublingual, heat-stable oxytocin tablets for postpartum hemorrhage: A simple, rapid, needle-free approach
Program for Appropriate Technology in Health (PATH) Seattle, WA, USA
Development of a low-cost, gravity fed blood separation unit

This project looks to develop a low-cost blood collection system that enables donated blood to be separated into red cells and plasma under gravity. The separation of whole blood into its component parts allows the donation to be shared amongst several patients based on volume required, and, more importantly, allows the most appropriate component to be transfused to the patient.

Development of a low-cost, gravity fed blood separation unit
Nonwovens Innovation And Research Institute Ltd. Leeds, West Yorkshire, UK
Low-Cost, Point-of-Care Paper-Based Microfluidic Diagnostics

Accurate, low-cost, point-of-care diagnostics for pregnant women and newborns are severely lacking in resource-limited rural settings. This leads to poor monitoring and late diagnoses of high risk pregnancies. To improve rural health care for expecting mothers and newborns, Diagnostics For All (DFA) proposes to develop two accurate, low-cost (<$0.10) postage stamp-sized paper-based diagnostics for expecting mothers and newborns that will be used to detect – and enable proper treatment of – (i) anemia and hyper/hypoglycemia and (ii) hypertensive disorders.

Low-Cost, Point-of-Care Paper-Based Microfluidic Diagnostics
Diagnostics For All, Inc Boston, MA USA
MOYO - Improved Fetal Health Rate Monitoring for Safer Births

Laerdal Global Health’s low-cost Fetal Heart Rate (FHR) monitor; MOYO and its training program will help providers measure FHR faster, automatically and more accurate to make timely obstetric responses when detecting fetuses at risk. This will reduce the burden of stillbirths and births asphyxia, estimated to account for 2million perinatal deaths annually. 98-99% of these deaths occur in low and middle-income countries. Expanding the use of MOYO to referring hospitals and dispensaries will help detecting fetuses at risk earlier and improve referrals.

MOYO - Improved Fetal Health Rate Monitoring for Safer Births
Laerdal Global Health Stavanger, Norway
PharmaChk: Substandard and Counterfeit Medicines Rapid Detection and Screening Platform

Substandard medicines account for approximately $75B of a $962B global pharmaceutical market and over 100,000 preventable deaths annually leading to tremendous financial loss and emergence of long-term drug resistance. Estimates indicate that 30-50% of all antimalarials are substandard. Additionally, while oxytocin has demonstrated high efficacy in saving lives of at-risk mothers, it routinely fails quality tests. Production and sale of substandard drugs are indicators of a compromised health system that greatly undermine health programs.

PharmaChk: Substandard and Counterfeit Medicines Rapid Detection and Screening Platform
Trustees of Boston University Boston, MA, USA
Inhaled Oxytocin - Landscape & Stakeholder Analysis in Regions with High Maternal Mortality

Oxytocin injection is the standard of care for the management of postpartum haemorrhage. Universal access to this essential medicine is currently limited in resource poor settings due to the requirement for refrigeration, consumables (needles, syringes etc.) and trained medical personnel for storage and administration. To address these roadblocks, Monash is seeking to develop an affordable heat-stable, self-contained, simple to administer inhaled delivery system for oxytocin.

Inhaled Oxytocin - Landscape & Stakeholder Analysis in Regions with High Maternal Mortality
Monash University Clayton, Victoria, Australia
Collaborative Community Based Technology To Improve Maternal and Child Health in Senegal

Senegal has one of the highest mortality rates with 370 maternal deaths per 100,000 live births, and neonatal and infant mortality rates at 47 and 55 per 1,000 respectively. These high mortality rates are due to poor access to health services. To increase demand for and access to quality maternal and neonatal services for women living in hard to reach areas of Senegal, Africare is proposing to develop an innovative model that integrates community based support services (Maternal Care Support Groups/MCSG) with mobile and telemedicine platforms.

Collaborative Community Based Technology To Improve Maternal and Child Health in Senegal
Africare Dakar, Senegal
The ReMiND Project - Reducing Maternal and Newborn Deaths

In a non-traditional partnership between non-profit and private sector, Catholic Relief Services is joining with technology innovator Dimagi and training leader Hesperian Foundation to improve maternal well-being and reduce newborn death by up to 50% in Uttar Pradesh, India. The ReMiND Project will accelerate the delivery of proven interventions within the first 48 hours of life through a novel combination of technology, training, and services for health workers and parents, including:  

The ReMiND Project - Reducing Maternal and Newborn Deaths
Catholic Relief Services Baltimore, MD, USA
Midwives Connect - Afghanistan

Despite foundational gains over the past decade, Afghanistan's maternal mortality rate remains among the world's highest, accounting for over five percent of all annual maternal deaths across the globe. Neonatal mortality remains equally abysmal.

Midwives Connect - Afghanistan
International Synergy Group, LLC, in partnership with Medweb Niceville, FL USA
Thermal images on Smartphones to diagnose bacterial neonatal pneumonia in Pakistan

Our objective is to develop a low-cost Smartphone attachment and application to diagnose and treat bacterial neonatal pneumonia in Pakistan. Currently, serious bacterial infection – pneumonia, sepsis and meningitis – results in preventable deaths of 700,000 neonates every year, 99% dying in resource limited settings such as Pakistan. Signs of serious infection in young babies are difficult to recognize. Diagnostic tests and chest X-rays are rarely available outside tertiary care hospitals.

Thermal images on Smartphones to diagnose bacterial neonatal pneumonia in Pakistan
Massachusetts General Hospital Boston, MA, USA
Preventing brain damage and hemodynamic shock after birth asphyxia.

Worldwide, almost 1 million babies die annually from birth asphyxia, 300.000 of them in Africa. There are no currently available pharmacological therapies for neonatal asphyxia. To fill this gap, we propose to administer to birth asphyxiated babies a nanosome preparation that has demonstrated in preclinical studies to be effective in the prevention of brain damage and control of hemodynamic shock, when given by intravenous route.

Preventing brain damage and hemodynamic shock after birth asphyxia.
Instituto de Investigaciones Biologicas Clemente Estable Montevideo, Uruguay
Non-contact Mobile Oximeter for Rapid Birth Asphyxia and Childhood Pneumonia Assessment

Oxygen saturation (SO2) is known as the 5th vital sign - a simple yet important reading strongly associated with various deadly neonatal complications during birth or postnatal care, including birth asphyxia and childhood pneumonia. Affordable oximeters are nearly non-existent in most first-level clinics where the majority of mothers and babies are initially treated - even present in some tertiary facilities, they are not suited for newborns due to a clip design and requirement of constant disinfection which is not realistic in the resource-poor regions.

Non-contact Mobile Oximeter for Rapid Birth Asphyxia and Childhood Pneumonia Assessment
Massachusetts General Hospital Boston, MA, USA
Scale-Up of Sustainable Ultrasound Delivery for Saving Lives at Birth

Over half of childbirth deaths in developing nations are attributed to treatable conditions such as hemorrhage from an abnormal placental location, fetal malpresentation, or obstructed labor. If identified in advance, such conditions can be prevented through life-saving treatment. In sub-Saharan Africa, a woman has 1 in 30 lifetime chance of dying from complications of childbirth. While ultrasound is effective in diagnosing many of these problems, traditionally it requires expensive equipment; high electrical power; and on-site, highly trained operators.

Scale-Up of Sustainable Ultrasound Delivery for Saving Lives at Birth
Imaging the World (ITW) Bellevue, WA USA
Comprehensive postpartum hemorrhage (PPH) control strategy in Myanmar that includes the controlled introduction of the non-pneumatic anti-shock garment (NASG)

In Myanmar, an estimated 80% of maternal deaths occur at home, and 31% are caused by postpartum hemorrhage. This project will work with the Ministry of Health (MOH) in Myanmar to help them achieve their goal of reducing maternal mortality by implementing a comprehensive postpartum hemorrhage (PPH) control strategy that includes the phased introduction of the non-pneumatic anti-shock garment (NASG) down to the lowest possible point of care. Although the WHO and the FIGO have both formally recommended use of the NASG, to date the NASG has only been used at the facility level.

Comprehensive postpartum hemorrhage (PPH) control strategy in Myanmar that includes the controlled introduction of the non-pneumatic anti-shock garment (NASG)
Program for Appropriate Technology in Health (PATH) Seattle, WA, USA
Healthcare System Integration of the Pratt Pouch for the Prevention of Transmission of HIV from Mother to Child

The transmission of HIV from mother to child during the birthing process can be largely prevented by the administration of ARV drugs. But, the newborn must start receiving medication within 24 hours after birth to be most effective. In Zambia, only 22.1% of infants born at home to HIV+ mothers receive the medication they need because it is difficult to get the medicine to them.

Healthcare System Integration of the Pratt Pouch for the Prevention of Transmission of HIV from Mother to Child
Duke University Durham, NC, USA
Application for Transition Grant

The persistence of mortality and severe morbidity from pre-eclampsia and eclampsia (PE/E) demands a new approach. Jhpiego—in a growing collaboration with Johns Hopkins University Center for Biomedical Innovation and Design (JHU-CBID), Laerdal Global Health, and other manufacturers—is making available new technologies and offering selected interventions through a new community-centered platform to reduce PE/E, the second leading cause of maternal mortality (after hemorrhage) worldwide.

Application for Transition Grant
Jhpiego Corporation Baltimore, MD USA
From reactive to proactive: reorganizing the labor ward to save lives

Using the principle that "every system is designed to get the results it gets," reorganizing the labor ward at Mulago Hospital is critical to combating the high rates of fetal, neonatal, and maternal death. With 100 deliveries per day, there are 3 intrapartum fetal deaths daily, 4 maternal deaths weekly, and a decision to cesarean interval of 6 hours. Cesareans account for 24% and vacuum for only 0.4% of deliveries.

From reactive to proactive: reorganizing the labor ward to save lives
Makerere University - Department of Obstetrics and Gynecology Kampala, Uganda
Integrated Technology, Distribution and Training Solution for Post-partum Hemorrhage (PPH)

Post-partum hemorrhage (PPH) is a leading cause of maternal mortality worldwide, responsible for one out of four maternal deaths and the suffering of more than eight of the 136 million women giving birth each year. Facility-based births have more than doubled to 55% of all births in India; however, these facilities lack trained staff, drugs and supplies needed to handle the rapid influx of births, especially in resource-poor settings, where women are at higher risk for death and disability from PPH.

Integrated Technology, Distribution and Training Solution for Post-partum Hemorrhage (PPH)
ayzh, Health and Livelihood Private Limited Chennai, Tamil Nadu, India
Saving Women's Lives by Simplifying the Treatment for Preeclampsia/Eclampsia with Rectally Delivered Magnesium Sulfate.

Preeclampsia and eclampsia (PE/E) are the second leading causes of maternal deaths and disability in developing countries, affecting thousands of pregnant women and their newborns each year. Magnesium sulfate (MgSO4) is considered the most effective, safe, and low-cost treatment for PE/E. Yet, MgSO4 continues to be greatly underutilized, especially in peripheral facilities, where the majority of women at high-risk deliver.

Saving Women's Lives by Simplifying the Treatment for Preeclampsia/Eclampsia with Rectally Delivered Magnesium Sulfate.
Program for Appropriate Technology in Health (PATH) Seattle, WA, USA
Reducing Maternal and Neonatal Mortality in South Sudan through Community-Based Health Training of Church "Safe Birth Committees" Combined with Building the Capacity of Traditional Birth Attendants and of Existing Health Facilities

This project will address the problem of high maternal and neonatal deaths in rural South Sudan as a result of multiple barriers left after years of civil war: traditional birth attendants (TBAs) and staff of rural government health clinics have inadequate training and resources to assess and manage pregnant women appropriately; there is lack of trust in and familiarity with these persons by pregnant women; and most homes are at remote distances from health clinics over undeveloped roads.

Reducing Maternal and Neonatal Mortality in South Sudan through Community-Based Health Training of Church "Safe Birth Committees" Combined with Building the Capacity of Traditional Birth Attendants and of Existing Health Facilities
South Sudan District of the United Methodist Church Yei, Central Equatoria, Sudan
Better Cord Care Saves Babies' Lives in Nepal

In Nepal, despite recent efforts to increase deliveries attended by a skilled provider, fewer than 20 percent are reached with such care. Much of the population faces significant geographic barriers to care, and a large proportion of newborns are exposed to poor hygiene conditions over their first few days of life. Nearly 70 percent of infant deaths occur within the first month of life, the most common cause being infection. A trial in Nepal has shown that risk of death can be reduced by 24 percent with application of the antiseptic chlorhexidine (CHX) to the umbilical cord stump.

Better Cord Care Saves Babies' Lives in Nepal
JSI Research & Training Institute, Inc. Boston, MA USA
Simulation based training for emergency cesarean section

A major cause of maternal and neonatal death and severe disability in developing countries is the lack of trained medical providers to perform emergency cesarean sections in cases of obstructed labor. Due to the shortage of doctors, many underserved countries rely on midwives and clinical officers to provide obstetrical care. These providers are not trained to perform cesarian section. A low cost method for training them to safely do this operation could reduce maternal/fetal mortality and devastating, non-lethal obstetrical complications such as recto-vaginal fistulas.

Simulation based training for emergency cesarean section
Operative Experience, Inc. Elkton, MD USA
A novel, simple method to find inexpensive drugs for preeclampsia treatment

Preeclampsia (PE) is a disease without targeted treatments. We propose a simple strategy to solve this problem: we will establish a cell-based assay to screen clinically-available, mostly generic and inexpensive, drugs that may have a therapeutic effect on PE. To do this, we will utilize new scientific knowledge, showing that anti-angiogenic factors released from the placenta trigger maternal vascular injury essential for the development of PE.

A novel, simple method to find inexpensive drugs for preeclampsia treatment
Queen's University Belfast Belfast, UK
Lifesaving Call box and telemedicine to increase access to Emergency Obstetric and Neonatal Care

Maternal and newborn death rates are still high in Tanzania. There is an insufficient number of healthcare workers with adequate skills to provide emergency obstetric (EmOC) and newborn care services in most health facilities. Poor road infrastructure and the long distance between health facilities has a negative impact on mentorship and technical support of health providers, as well as patient referrals.

Lifesaving Call box and telemedicine to increase access to Emergency Obstetric and Neonatal Care
MANAGEMENT AND DEVELOPMENT FOR HEALTH Dar Es Salaam, Tanzania
The 3R Blood Donor Project: recognition, recall and repeat donation to transform access to safe blood transfusion

Timely access to safe blood transfusion is an essential component of antepartum, postpartum, and post-abortion care to prevent deaths from haemorrhage and severe anaemia. Peri-partum haemorrhage alone accounts for 34% of obstetric deaths in Africa and is an important cause of stillbirths and neonatal deaths. Access to safe blood for transfusion is an integral component of comprehensive emergency obstetric care. A major roadblock to the provision of blood transfusions in low/middle-income countries is not enough safe blood in the right place at the right time.

The 3R Blood Donor Project: recognition, recall and repeat donation to transform access to safe blood transfusion
Liverpool School of Tropical Medicine Liverpool, UK
Saving mothers and babies with reliable solar power

In Uganda, each year an estimated 6,000 women and 35,000 infants die from childbirth related complications. Access to skilled health care and appropriate technologies can save many lives. But in many countries, the difference between life and death for is dependent upon reliable light and electricity. Without that, health workers cannot provide life-saving care. Midwives struggle to deliver babies by candlelight, life-saving procedures are attempted by flashlight, and patients suffer delays in care or are turned away from health centers unable to function in darkness.

Saving mothers and babies with reliable solar power
African Medical Research Foundation(AMREF) in Uganda Kampala, Uganda
Empowering Women Through Radio: A Demand Driven Communication Strategy in Tanzania and Uganda

Maternal and newborn death and sever illness is tragically high in Uganda and Tanzania. There are many reasons for this. Less than 50% of all births are attended by skilled health professionals. Malaria in expectant mothers is a very common yet preventable cause of anemia and death for newborns and mothers. Failure to access the right care at the right time means that minor obstetric complications threaten the health and survival of mother and child. Governments are beginning to rise to these challenges by creating enabling policies and programs.

Empowering Women Through Radio: A Demand Driven Communication Strategy in Tanzania and Uganda
World University Service of Canada Ottawa, Canada
NanoACT : a placenta-seeking nanoparticle containing artemisinin-lumefantrine

Pregnancy associated malaria results in poor pregnancy outcomes such as intra-uterine growth retardation (IUGR), stillbirths, premature and low birth weight (LBW, < 2,500 g) deliveries, and congenital and neonatal malaria which adversely affect neonatal survival. The standard practice involves antimalarial prophylaxis during pregnancy by intermittent preventive therapy (IPT) with sulfdoxine-pyrimethamine (SP). However, there is mounting concern about possible IPT failure due to escalating SP resistance and risk of severe SP toxicity.

NanoACT : a placenta-seeking nanoparticle containing artemisinin-lumefantrine
Institute of Primate Research Nairobi, Kenya
Online matching to propagate innovations in maternal and newborn care: Better. Together.

We propose to develop a low-cost scalable mechanism for south-south collaboration among developing country frontline providers, using social networking technology to significantly expand the use of evidence-based practices known to reduce maternal and perinatal deaths. This project capitalizes on the success of the Global Voices for Maternal Health Project that has created, in eight months, a unique network of 2,500 engaged nurses, midwives and doctors working in 900 health facilities located in 99 developing countries, who provide care to over 3,000,000 births a year (see map).

Online matching to propagate innovations in maternal and newborn care: Better. Together.
President & Fellows of Harvard College Boston, MA USA
The Baby Game: Using gamification to increase utilization of health centers by pregnant women.

Rationale: Cambodia's maternal and neonatal mortality rates remain unacceptably high. Only 54% of mothers deliver in a facility, and increasing utilization of health centers is central to the government's strategy.

The Baby Game: Using gamification to increase utilization of health centers by pregnant women.
Cambodia Health Education Media Service (CHEMS) Phnom Penh, Cambodia
Nanobiosym Pilot: Optimization and Evaluation of Gene-RADAR® Nanotech platform Point-Of-Care HIV Diagnostic Device Prevention of Mother-To-Child Transmission in Rwanda

In Rwanda, 90% of all cases of infant and child HIV infections occur through mother-to-child transmission (MTCT). Studies led by Dr. Katherine Luzuriaga demonstrated that early antiretroviral therapy (ART) markedly reduces HIV-related mortality in infants. However, in resource limited settings, the lack of molecular diagnostic methods for early infant diagnosis prevents the timely application of lifesaving HIV therapy.

Nanobiosym Pilot: Optimization and Evaluation of Gene-RADAR® Nanotech platform Point-Of-Care HIV Diagnostic Device Prevention of Mother-To-Child Transmission in Rwanda
Nanobiosym, Inc Cambridge, MA, USA
Sublingual oxytocin in a fast-dissolving tablet: human pharmacokinetic study of a novel, needle-free, temperature-stable treatment for prevention of postpartum hemorrhage

Postpartum hemorrhage (PPH) continues to be a major cause of maternal mortality globally, especially in low-resource settings where most women lack access to quality, assisted delivery by skilled birth attendants and are at high risk for suffering PPH. PPH can be effectively prevented by the intramuscular delivery of oxytocin (WHO’s preferred drug of choice for PPH prevention) but issues with oxytocin stability and the administration route have limited its availability in low-resource settings.

Sublingual oxytocin in a fast-dissolving tablet: human pharmacokinetic study of a novel, needle-free, temperature-stable treatment for prevention of postpartum hemorrhage
PATH Seattle, WA, USA
3rd trimester, point-of-care, pocket ultrasound protocol by midwives to prevent maternal and perinatal mortality in rural Kenya, Ghana, Burundi, Haiti, and Peru

We aim to detect rural pregnancies at high-risk of maternal and perinatal mortality by training nurse-midwives to incorporate a simple, one-time, point-of-care, 3rd trimester ultrasound into their routine practice. Standard-of-care in most rural, resource-limited settings does not include prenatal ultrasound. Traditional barriers include limited training opportunities for non-physicians and lack of evidence around best practices for screening when presentation is delayed until 3rd trimester or onset of labor.

3rd trimester, point-of-care, pocket ultrasound protocol by midwives to prevent maternal and perinatal mortality in rural Kenya, Ghana, Burundi, Haiti, and Peru
University of Toronto, Sunnybrook Research Institute Toronto, Ontario, Canada
Point-of-care diagnosis of active syphilis for the elimination of congenital syphilis

This project will optimize and validate an innovative, specific and sensitive point-of-care test, which, for the first time, will rapidly and accurately diagnose active syphilis and allow for immediate treatment at the point of care. This diagnostic test could therefore result in significant improvements in the health of women and children through prevention of stillbirths and severe neonatal morbidity and mortality associated with congenital syphilis.

Point-of-care diagnosis of active syphilis for the elimination of congenital syphilis
Burnet Institute Melbourne, Australia
Comet: Effective, compact, and low-cost phototherapy to treat newborn jaundice

Sixty percent of all newborns develop jaundice after birth. Of them, over twelve percent need immediate treatment for severe jaundice. Without timely treatment, newborns may suffer kernicterus (brain damage) and death. Unlike malaria or HIV, jaundice is a simple problem to solve: treatment is phototherapy in the form of intense blue lights. However, in low-resource clinics and hospitals around the world, existing phototherapy options - if they exist - are often ineffective, costly, difficult to maintain, and improperly used.

Comet: Effective, compact, and low-cost phototherapy to treat newborn jaundice
D-Rev: Design for the Other Ninety Percent Palo Alto, CA USA
Integrating Innovations Towards Improved Maternal and Newborn Health in Rural Lesotho

No single intervention can effectively address the maternal and neonatal health crisis in Lesotho, given the complexity of structural barriers to care; the low demand for services for maternal and neonatal health (MNH) and their low quality; and the unrelenting HIV epidemic. Thus, we propose an innovative combination approach that bundles evidence-based MNH and HIV interventions with incentives for participating individuals and health facilities based on all-or-none accomplishment.

Integrating Innovations Towards Improved Maternal and Newborn Health in Rural Lesotho
The Trustees of Columbia University in the City of New York New York, NY USA
"Omeed-e-kodak" Hope of the babies: An innovative approach empowering women to knit baby sweaters and hats and use mobile phones to increase the numbers of antenatal care visits, births by skilled attendants, postpartum visits and birth registration

Rationale: Maternal and newborn mortality and morbidity are high in Afghanistan. Rates of antenatal care, skilled attendant at birth and postpartum care are low. The Afghan Mortality Survey 2010 found that the reasons for not using health services often related of not understanding the need for care. Therefore the links between communities and health providers and facilities need to be strengthened.

"Omeed-e-kodak" Hope of the babies: An innovative approach empowering women to knit baby sweaters and hats and use mobile phones to increase the numbers of antenatal care visits, births by skilled attendants, postpartum visits and birth registration
World Health Organization Geneva, Switzerland
Testing the Positive Deviance Approach for Maternal and Neonatal Health

Rationale: A lack of staff and equipment, travel, and traditional practices cause 46% of Cambodian women to deliver at home. Addressing these issues will take many decades, so in the meantime a new approach is needed that can be implemented with existing resources.

Testing the Positive Deviance Approach for Maternal and Neonatal Health
Cambodian HIV/AIDS Education and Care (CHEC) Phnom Penh, Cambodia
Clean Births Are Safe Births: Social Marketing of Clean Birth Kits

A long-entrenched problem in Pakistan is that the poorest women are unable to access functioning health-centres owing to difficulties in physical access, cost constraints, lack of staff and socio-cultural barriers to travelling. In rural areas 75% births take place at home in unhygienic conditions under the supervision of traditional birth attendants. Therefore, neonatal infections are contracted during and immediately after delivery.Clean birth kits (CBKs) are scientifically proven to enable safer home births by preventing life threatening neonatal infections.

Clean Births Are Safe Births: Social Marketing of Clean Birth Kits
Pakistan National Forum on Women's Health Karachi, Pakistan
Improving utilization of antenatal care and access to skilled delivery services through phones and health kiosks

Interventions to improve maternal and newborn outcomes in resource limited regions such as Kenya are successful when they aim at improving knowledge on danger signs of pregnancy, advice on when to seek assistance, and increase health facility deliveries. We propose a public-private partnership program to promote quality, timely utilization, and monitoring of focused ante-natal care and skilled delivery services. This will be through a network between health facilities and solar-powered community health kiosks (M-Afya kiosks) connected through mobile phone telephony .

Improving utilization of antenatal care and access to skilled delivery services through phones and health kiosks
Afya Research Africa Thika, Kenya
mBirthCare - Integrating basic primary birth care and mHealth records in Sub-Saharan Africa

Rationale: Facility-based births must be superior to home deliveries for both the mother and the infant. This is not always the case in remote poorly equipped first level maternities in SubSaharan Africa with poorly trained staff. 

mBirthCare - Integrating basic primary birth care and mHealth records in Sub-Saharan Africa
University of Bergen, Norway Bergen, Norway
HIST-BIRTH: Innovative and rapid point-of-care histone test strips for early diagnosis of sepsis in pregnancy and childbirth.

Documented incidence of sepsis worldwide is 1.8 million cases annually, and it is increasing in low-income countries and vulnerable populations, such as pregnant women and infants (75,000 maternal/1 million newborn deaths year). Given this devastating scenario it is imperative to seek new strategies based on scientific findings and the application of innovative technologies to minimize the social impact of sepsis. Based on these assumptions, and using science and technological approaches, we propose to develop a rapid, low-cost and effective method for detecting sepsis in early stages.

HIST-BIRTH: Innovative and rapid point-of-care histone test strips for early diagnosis of sepsis in pregnancy and childbirth.
University of Valencia Valencia, Spain
Regional Scale-up of Helping Babies Breathe in sub-Saharan Africa

The American Academy of Pediatrics and Save the Children/Saving Newborn Lives, as partners in the Helping Babies Breathe® Global Development Alliance (GDA), will form a regional alliance with three countries in Sub-Saharan Africa (Kenya, Malawi, and Uganda).

Regional Scale-up of Helping Babies Breathe in sub-Saharan Africa
American Academy of Pediatrics Elk Grove Village, IL USA
Village Birthing Teams: Impact of combined, evidence-based interventions to prevent maternal and newborn complications and timely access to emergency care.

While there is global agreement that investing in health systems is critical to reducing maternal and newborn mortality, complimentary community-based approaches have been given less attention. Recently it has been acknowledged that a mobilized community which acts to support families, communities and mothers knowledge around pregnancy and birth will contribute significantly to a reduction in maternal and newborn mortality.

Village Birthing Teams: Impact of combined, evidence-based interventions to prevent maternal and newborn complications and timely access to emergency care.
World Vision, Inc. Federal Way, WA USA
The WHO Mother Baby mCheck Tool project in India

 Almost two-thirds of neonatal deaths, and a high proportion of maternal deaths, occur within the first 7 days after delivery. It is often assumed that patients can recognize severe complications, when to seek care, and feel empowered to do so. Very often; however, this is not the case. During this high-risk period immediately after birth, mothers are often at home with no monitoring from skilled providers. Mothers can be unsure of whether certain symptoms are normal and, more importantly, often are not empowered to seek care even when experiencing a severe complication.

The WHO Mother Baby mCheck Tool project in India
World Health Organization PSP/CPO Geneva, Switzerland
Taking First Embrace to Scale

Maternal and neonatal death rates are high in the Western Visayas region of the Philippines, where access to skilled birth attendants is relatively high but compliance with appropriate antenatal care (ANC) and postnatal care (PNC) practices is poor. World Health Organization (WHO) essential protocols for reducing maternal and infant mortality are not extended into the communities or into the homes, where many women give birth. Government services are are delivered through separate, vertical, poorly-coordinated programs. 

Taking First Embrace to Scale
Helen Keller International, The Philippines Manilla, Philippines
Applying Low Cost Health and Information Technologies at the Community and Clinic Level in Rural India

Healthpoint Services India Pvt. Ltd (“eHealthPoint”) proposes to deploy maternal/child health services that leverage its existing innovative rural healthcare delivery model while adding cutting-edge mHealth tools to reach out to surrounding communities.

Applying Low Cost Health and Information Technologies at the Community and Clinic Level in Rural India
Healthpoint Services Secunderabad, India
Accelerating introduction of dual syphilis/HIV rapid diagnostic tests

Elimination of mother-to-child transmission of syphilis and HIV directly contributes towards attaining Millennium Development Goals 4 (neonatal health), 5 (maternal health), and 6 (HIV prevention). However, in 2010, only 68% of pregnant women in low-and middle-income countries were tested for syphilis, and only 35% were tested for HIV. As a result, syphilis contributed to 440,000 stillbirths and neonatal deaths in 2008, and 390,000 children were newly infected with HIV in 2010.

Accelerating introduction of dual syphilis/HIV rapid diagnostic tests
World Health Organization Geneva, Switzerland
Blood Safety Microchip

Blood transfusions in the countries of sub-Saharan Africa and Southeast Asia are critically important. The low standard of living and malnutrition in these countries leads to high frequency of anemia, particularly in children and women. According to World Health Organization (WHO) 30 to 40% of women in sub-Saharan Africa have anemia and about 25% of postpartum deaths in women are related to obstetrical hemorrhages. While blood transfusions are essential, blood safety remains a major problem in the developing world.

Blood Safety Microchip
The Regents of the University of California Davis, CA USA
Phase I Clinical Evaluation of Inhaled Oxytocin

This project will involve the development of a novel aerosol delivery system for oxytocin that can be inhaled by patients from a simple, disposable device immediately after childbirth for the management of postpartum hemorrhage (PPH). This approach will address several of the current roadblocks to healthy pregnancies by (a) providing a more stable formulation of oxytocin that does not require cold-chain storage, and (b) removing the need for highly trained health workers for administration.

Phase I Clinical Evaluation of Inhaled Oxytocin
Monash University Clayton, Austrailia
Clinical Care Algorithms of Proven Interventions to Achieve a High Standard of Perinatal Care

Rationale: Improve perinatal outcomes by fully utilizing existing resources and raising quality of services by implementing standardized perinatal care to prevent and manage complications of labor and delivery (stillbirth, prematurity, obstructed labor).

Approach: Introduction of concise evidence-based care algorithms to improve service delivery that are rapidly adapted to local conditions to directly address entrenched challenges in the adequacy and timeliness of care for immediate threats to mothers and newborns.

Clinical Care Algorithms of Proven Interventions to Achieve a High Standard of Perinatal Care
Seattle Children's Hospital Seattle, WA USA
An integrated community-to-facility approach to saving lives at birth in rural Nepal

Reducing late fetal (1.2 million), maternal (150,000), and early neonatal (1.4 million) deaths remains the most critical global health challenge. Additionally 1.4 million women suffer severe acute morbidities (“near miss”).  Development and scaling of innovative approaches to provision of simple cost-effective interventions to improve intrapartum outcomes is needed.

An integrated community-to-facility approach to saving lives at birth in rural Nepal
The Johns Hopkins University Baltimore, MD, USA
Low-Cost Respiratory Support: Reducing Early Neonatal Death in Rural Malawi

Acute respiratory infections are the leading cause of global child mortality. In the developing world, oxygen therapy is often the only treatment option for babies who are suffering from respiratory distress. Without the added pressure of a bubble Continuous Positive Airway Pressure (bCPAP), babies still struggle to breathe and can suffer serious complications, and frequently death. A stand-alone bCPAP device can cost $6,000, too expensive for most developing world hospitals.

Low-Cost Respiratory Support: Reducing Early Neonatal Death in Rural Malawi
William Marsh Rice University Houston, TX USA
Extremely affordable solar-powered infant warmer to complement skin-to-skin care

Each day, 3,100 newborns die worldwide within 24 hours of birth. Ninety percent of these babies could be saved if breastfeeding and warmth are provided immediately. Very small babies (newborns weighing less than 1,800 grams) often are also very sick and should be cared for with a thermoregulation device initially, and managed with skin-to-skin care once they become stable. If such babies are not treated, they can suffer complications of hypothermia, including respiratory distress, acidosis, hypoglycemia, and even death.

Extremely affordable solar-powered infant warmer to complement skin-to-skin care
Program for Appropriate Technology in Health (PATH) Seattle, WA USA
Removing Barriers for Sustained Reduction of Maternal and Newborn Mortality in Rural Zambia

This integrated innovation engages elected rural ward councilors in rural Zambia to remove local barriers to use of key antenatal, intra-partum, and postnatal care services and practices in a poor, under-served constituency. Locally-elected representatives, though rarely convoked to improve maternal-newborn care (MNC) directly, constitute a promising, but untested, entry point to save lives by strengthening leadership skills and democratic processes.

Removing Barriers for Sustained Reduction of Maternal and Newborn Mortality in Rural Zambia
Save the Children Federation, Inc Westport, CT USA
Use of mobile technology and pay-it-forward business model

Malezi-Bora is a mobile application, availed in local languages, with audio content regarding maternal and newborn health. It works on ultra-low-cost handsets and leverages village social networks. It utilizes a pay-it-forward business model, designed to incentivize mothers to virally share its content, and mapping technology to identify mothers in distress. The application focuses on addressing the inability of current health information-sharing systems gaining critical-mass usage and the inability of community health workers to reach every mother.

Use of mobile technology and pay-it-forward business model
Zoe Alexander Ltd Nairobi, Kenya
Low-cost Mobile Platform for Real-Time Monitoring of Blood Loss

Obstetric hemorrhage is the leading cause of maternal mortality in developing countries, with over 95% of the 350,000 worldwide annual deaths occurring in Africa and Asia. Real-time monitoring of maternal blood loss is crucial in allowing for preventive interventions within a critical timeframe. Visual estimation of blood loss (EBL) by health workers is a widely adopted monitoring practice, but its accuracy is severely limited by human error and insufficient training and attention; health workers miss the onset of post-partum hemorrhage in over 80% of cases when visual estimation is used.

Low-cost Mobile Platform for Real-Time Monitoring of Blood Loss
Board of Trustees of the Leland Stanford Junior University Menlo Park, CA USA
Embrace: Integrating Thermal Support Devices Into Vietnam's Infant Transport System To Improve Health Outcomes Among Low Birth Weight Neonates

Low birth weight (LBW) infants are at higher risk of hypothermia due to their increased surface-to-mass ratios; studies indicate that the prevention and management of hypothermia through thermoregulation can reduce neonatal mortalities by up to 42%. Roughly 500 district hospitals in Vietnam lack neonatal intensive care units, forcing them to transfer infants with pathologies to provincial hospitals. Transport is unsophisticated and lacks standardization; ambulances, when available, are not equipped to provide thermoregulation. Transport is the weak link in the warm chain.

Embrace: Integrating Thermal Support Devices Into Vietnam's Infant Transport System To Improve Health Outcomes Among Low Birth Weight Neonates
Embrace San Francisco, CA USA
Development of a Freestanding, Portable, Solar-Powered, LED-based Phototherapy Device

Severe bilirubin encephalopathy from inadequately treated jaundice is a global health threat to newborns. Developing areas in Africa, the Middle East, and Southern Asia that have a high prevalence of the heritable hemolytic condition, G6PD deficiency, are particularly vulnerable, and numerous countries in those regions report jaundice as the second or third leading cause of neonatal death.

Development of a Freestanding, Portable, Solar-Powered, LED-based Phototherapy Device
Children's Hospital Boston Boston, MA USA
Tampostat: A low-cost, self-regulating tamponade for management of postpartum hemorrhage in low-resource settings

Postpartum Hemorrhage (PPH), the leading cause of maternal mortality worldwide, affects 14 million women and claims 150,000 lives annually. 99% of deaths occur in low-resource settings, where the majority of women give birth at home. The primary cause of PPH is uterine atony (80% of cases) and treatment includes administering uterotonic drugs to induce contraction and applying pressure on the uterine surface to minimize blood loss.

Tampostat: A low-cost, self-regulating tamponade for management of postpartum hemorrhage in low-resource settings
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) Dhaka, Bangladesh
Mobile Community Childbirth Checklist (mCommCC) for mothers and layperson referral gatekeepers: danger sign recognition, emergency preparedness, and linkages to skilled care

In Bangladesh, 77% of births occur outside a facility and 72% without a skilled attendant. When maternal or neonatal complications occur, <40% of women seek care, mainly due to misunderstanding of complication severity and/or necessity for referral; relatives or neighbours are the primary referral sources. Antenatal care coverage and logistical preparation for childbirth emergencies are also poor. An intervention to empower mothers and layperson referral gatekeepers to overcome these logistical, knowledge, communication gaps is urgently needed.

Mobile Community Childbirth Checklist (mCommCC) for mothers and layperson referral gatekeepers: danger sign recognition, emergency preparedness, and linkages to skilled care
International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) Dhaka, Bangladesh
Enhanced Lateral Flow Assay for Detecting Combinations of Preeclampsia Biomarkers

Many recent studies have concluded that detecting the presence of multiple biomarkers at once is most promising for predicting and diagnosing preeclampsia rapidly and at the point-of-care (POC). Therefore, developing affordable and effective multiplexed tests will improve maternal health and pregnancy outcomes. Our idea is to develop a simple, rapid, and low-cost method for detecting combinations of preeclampsia biomarkers to enable early detection at the POC in Zambia and other LMICs.

Enhanced Lateral Flow Assay for Detecting Combinations of Preeclampsia Biomarkers
Vanderbilt University Nashville, TN, USA
Seeking Synchrony for Immunization, Family Planning and Growth Monitoring

The six-week well-baby visit is crucial to the health of the postpartum mother and her baby. For the infant, the visit includes growth monitoring and crucial immunizations. Many mothers also accept family planning (FP) at this time (typically DMPA or pills in sub-Saharan Africa). After the six-week visit, the follow-up schedule for both immunization and FP includes three more visits during the first year, but not a single one of these six visits overlaps!

Seeking Synchrony for Immunization, Family Planning and Growth Monitoring
Family Health International (FHI 360) Durham, NC, USA
PIERS on the Move: Pre-eclampsia Integrated Estimate of RiSk assessment on a mobile phone

Worldwide pre-eclampsia is the 2nd leading cause of maternal death, killing 76,000 pregnant women and 500,000 fetuses and infants each year. With Saving Lives at Birth (2011) seed funding, we developed a ground-breaking solution to this global health challenge. "PIERS on the Move" integrates our two innovations: the miniPIERS (Pre-eclampsia Integrated Estimate of RiSk) predictive model, which can accurately stratify women into risk categories up to a week before complications arise and without laboratory tests; and the Phone Oximeter.

PIERS on the Move: Pre-eclampsia Integrated Estimate of RiSk assessment on a mobile phone
The University of British Columbia Vancouver, British Columbia, Canada
Post-Partum Intrauterine Device Inserters

Immediate postpartum intrauterine device (PPIUD) insertions (within 10 minutes to 48 hours post-delivery) offer a novel and convenient method to increase contraceptive uptake in developing countries. However, a dedicated PPIUD inserter is currently not available. As a workaround, forceps are used- the IUD is taken out of the traditional interval inserter (used for insertions after four weeks postpartum), and grasped with forceps before it is placed at the uterine fundus. However, sterile forceps may not always be available.

Post-Partum Intrauterine Device Inserters
Population Services International Washington DC, USA
Antenatal Disease Diagnosis and Reporting Instrument

We propose developing a new, low cost instrument to rapidly and accurately diagnose and report important diseases of maternal child health (MCH) in rural locations of low and middle income countries. We will start with four important MCH diseases: anemia, HIV, syphilis and malaria.

Antenatal Disease Diagnosis and Reporting Instrument
Global Solutions for Infectious Diseases San Francisco, CA USA
Preventing Neural Tube Defects in Nicaragua through Rice Fortification

Neural tube defects (NTDs) are a group of preventable birth defects that result in severe neurologic and functional disabilities and usually death. The incidence of NTDs in Nicaragua is nearly ten-fold higher than in the United States, where NTDs are prevented through mandatory fortification of staple foods with folic acid. This project will prevent neural tube defects in Nicaragua through fortification of rice – a staple food – with folic acid.

Preventing Neural Tube Defects in Nicaragua through Rice Fortification
INCAP Managua, Nicaragua
Chama for Change: Scaling-up an integrated community-based strategy of peer support in pregnancy and infancy

Worldwide, women and children in poor and rural communities face the challenges of pregnancy and infancy without supports in the home, community, or facility. It is no surprise that the majority of women struggle to care for their own and their children’s health. To address this, we have dared to build on the existing Three Delays Model, to tackle a critical 4th delay: the delay in a community’s accountability to its mothers and infants. We developed a peer-support model that groups pregnant and breastfeeding mothers to receive antenatal and postnatal services.

Chama for Change: Scaling-up an integrated community-based strategy of peer support in pregnancy and infancy
Moi University College of Health Sciences Eldoret, Kenya
On site, fast and low cost diagnostic of tuberculosis and HIV for mothers and newborns

We propose the use of a diagnostic technology for TB and HIV based in the use of a chimeric recombinant antibody obtained from a marine organism and modified by genetic engineering, which when added to a sample of blood from a patient infected by a certain disease will produce a visual reaction in the sample allowing the user to do a simple and fast screening of infected patients. This process does not require any kind of equipment and the user can use the test even without previous training.

On site, fast and low cost diagnostic of tuberculosis and HIV for mothers and newborns
Unima Jalisco, Mexico
An integrated low cost technology for identifying preterm/low birth weight babies and linkage to quality care in a rural setting

The essence of our idea is to develop a low cost simple technology that can be used by community health workers to identify low birth weight babies including preterm, and through facilitated referral link them to facility care. Complications of prematurity and low birth weight (LBW) are the number one leading cause of newborn deaths, up to 70% in some developing countries where almost half of the deliveries are at home.

An integrated low cost technology for identifying preterm/low birth weight babies and linkage to quality care in a rural setting
Makerere University School of Public Health Kampala, Central Uganda
Que Vivan Las Madres: Scaling Up an Integrated Approach to Reduce Maternal and Perinatal Mortality in Northern Guatemala

Guatemala has one of the highest national maternal mortality ratios in Latin America at 149 per 100,000 live births, and up to 260 per 100,000 in some northern departments. Only 31% of deliveries are attended by a skilled birth attendant. Since early 2004 Guatemala has invested heavily in building and updating northern clinics for 24 hour delivery care. It was expected that as access increased, rates of maternal and perinatal mortality would drop. But as of 2012 this had not occurred.

Que Vivan Las Madres: Scaling Up an Integrated Approach to Reduce Maternal and Perinatal Mortality in Northern Guatemala
Epidemiological Research Center in Sexual and Reproductive Health Guatemala City, Guatemala
A Novel Agent for Management of Post Partum Hemorrhage: Adaptation of the Xstat Mini-Sponge Applicator for Obstetric Use

Postpartum hemorrhage (PPH) is the leading cause of maternal mortality in low-income countries. The majority of these deaths occur outside the health care system, and so an intervention that could be used in any setting and with minimal training could save lives. We will use an animal model to demonstrate appropriate uterine fill, and a proof-of-concept study to show stoppage of post-delivery bleeding and test ease of removal.

A Novel Agent for Management of Post Partum Hemorrhage: Adaptation of the Xstat Mini-Sponge Applicator for Obstetric Use
Oregon Health and Science University Portland, OR, USA
High-Performance, Low-Cost Diagnosis of Neonatal Sepsis at the Point-of-Care

Neonatal sepsis accounts for 15% of the 3 million neonatal deaths worldwide. 98% of all neonatal sepsis deaths occur in developing regions, where there is a lack of adequate sepsis diagnostics. Rapid, point-of-care sepsis diagnostics have the potential to significantly decrease neonatal mortality in the developing world. To meet this need, we propose to develop a rapid, low-cost, quantitative point-of-care diagnostic test for neonatal sepsis for low-resource settings.

High-Performance, Low-Cost Diagnosis of Neonatal Sepsis at the Point-of-Care
Rice University Houston, TX, USA
PIERS on the Move - transitioning from pre-eclampsia to pregnancy and neonatal care

Every day, 750 pregnant women, 7200 fetuses, and 8200 newborns die - almost uniformly from preventable causes. Over 99% of those deaths occur in less developed countries, often shortening the lives of individuals who have been unable to access effective health care (either at all or in time). Generally, women die from complications of pregnancy and childbirth that lead either to low (bleeding, prolonged labour, and sepsis) or high (hypertension) blood pressure, as well as intercurrent illnesses (HIV, malaria, and tuberculosis).

PIERS on the Move - transitioning from pre-eclampsia to pregnancy and neonatal care
University of British Columbia Vancouver, BC, Canada
ACT for Birth, Uganda (A=audit, C=cell phones, T=technology and training)

Each year millions of births, including those in facilities, occur without effective monitoring or appropriate response. The baby’s heart rate is the most important signal of distress in labor. Inadequate heart rate monitoring and failure to respond to distress is an important determinant of almost 1 million newborn deaths and 1.2 million stillbirths each year globally. Effective monitoring during labor in challenging settings depends on rugged, reliable, simple devices able to be used without electricity or batteries.

ACT for Birth, Uganda (A=audit, C=cell phones, T=technology and training)
Save the Children Federation, Inc Westport, CT USA
Low-cost, point-of-care screening and diagnosis of preeclampsia/eclampsia: novel biomarkers in a lateral-flow test

The World Health Organization estimates that PE/E accounts for at least 16% of maternal deaths in low-resources settings. The risk of dying from PE/E is approximately 300 times higher for a woman in a developing country than for a woman in a developed country. Automated diagnostic systems for detection of blood biomarkers with higher accuracy and better predictive values (e.g., Alere Triage® PlGF test; 96% sensitivity, 98% negative predictive value) are commercially available.

Low-cost, point-of-care screening and diagnosis of preeclampsia/eclampsia: novel biomarkers in a lateral-flow test
PATH Seattle, WA, USA
Reduction of infant intrauterine growth retardation (IUGR) through Direct Observation Dietary Supplementation (DODS) of malnourished pregnant women with early identification of at-risk newborns through mobile technologies in rural Gujarat

Nearly half of all infant deaths occur in the first 28 days after birth, with prematurity and low birth weight as leading causes. We propose to assess the feasibility of development and distribution of an indigenous energy protein supplement to at-risk pregnant women attending health centers in rural Gujarat to reduce infant intrauterine growth retardation and monitor key biological parameters of their at-risk infants through a low cost mobile device.

Reduction of infant intrauterine growth retardation (IUGR) through Direct Observation Dietary Supplementation (DODS) of malnourished pregnant women with early identification of at-risk newborns through mobile technologies in rural Gujarat
Harvard School of Public Health Boston, MA USA
Saving Hearts and Mothers At Birth

One out of every 1000 births throughout Africa inexplicably leads to maternal heart failure, known as peripartum Cardiomyopathy (PPCM). 20% of these women die, as do most of their newborn children. The only treatment for severe PPCM is cardiac transplantation-- not a feasible option in the developing world. The cause of PPCM remained unclear until recently. Our recently published work has identified endogenous anti-vascular factors as triggers for PPCM. We have now additionally discovered a class of medications that blocks secretion of these factors.

Saving Hearts and Mothers At Birth
Beth Israel Deaconess Medical Center Boston, MA, USA
Bili-Hut: Saving newborn lives with rapid deployment of phototherapy in rural India

Brain injury and death from severe neonatal jaundice is a preventable global health tragedy. Despite the relative simplicity of the cure, blue light phototherapy, rapid deployment of this treatment in rural, low resource areas of India has proven to be logistically challenging due to high equipment cost, distribution difficulties, and unreliable line power. Infants requiring phototherapy must be transported to urban referral facilities, often traveling for many hours. The resulting treatment delay places these newborns at high risk for adverse outcomes.

Bili-Hut: Saving newborn lives with rapid deployment of phototherapy in rural India
Little Sparrows Technologies Winchester, MA, USA
mLabor: a mobile application to support labor monitoring and the early detection and management of serious maternal and fetal complications

Prolonged and obstructed labor is one of the leading causes of maternal and newborn mortality and of serious maternal morbidities, such as obstetric fistula. Currently, a low-tech paper form—the partograph—is universally recommended by the World Health Organization. However, despite decades of training and investment, correct use of the paper partograph remains low. We propose an innovative use of Smartphone and tablet technology to improve the service delivery provided by health workers to detect and correctly manage these complications.

mLabor: a mobile application to support labor monitoring and the early detection and management of serious maternal and fetal complications
Dimagi, Inc. Cambridge, MA, USA
SafeSnip is an obstetric device that cuts, clamps, and shields infants, mothers, and birthing personnel from infection

NOvate Medical Technologies, LLC ("NOvate") is a New Orleans-based medical device development company focused on commercializing high-quality, low-cost medical products. NOvate is committed to delivering medical solutions, novel training programs, and information technologies which address the health needs of the developing world. NOvate's first product offering, SafeSnip, is a patent-pending disposable and degradable plastic obstetric device that simultaneously cuts, clamps, and shields the umbilical cord from infection.

SafeSnip is an obstetric device that cuts, clamps, and shields infants, mothers, and birthing personnel from infection
NOvate Medical Technologies, LLC New Orleans, LA USA
Mobile Applications for Comprehensive Management of Preeclampsia and Eclampsia

PATH proposes to develop a comprehensive set of mobile applications to support health care providers to more effectively manage women with severe preeclampsia and eclampsia (PE/E). The four applications will be designed as interactive job aids, guiding health care providers through four key components of care—anticonvulsive drugs, antihypertensive drugs, fluid administration, and timed childbirth: 1. Administration of loading and maintenance doses of magnesium sulfate (MgSO4); 2. Administration of antihypertensive drugs; 3. Administration of fluids; and 4.

Mobile Applications for Comprehensive Management of Preeclampsia and Eclampsia
PATH Seattle, WA, USA
Simple and Rapid Diagnosis of Preeclampsia

Preeclampsia is a pregnancy-related hypertensive disorder affecting 2 to 8% of all pregnancies and a major cause of maternal and antenatal mortality in the developing world. Key pathophysiological processes are initiated by impaired early trophoblastic invasion and overproduction of angiogenic factors. A panel of predictive biomarkers reflecting different aspects of the disease offers the potential to diagnose preeclampsia at an early stage in gestation.

Simple and Rapid Diagnosis of Preeclampsia
Becton, Dickinson and Company Research Triangle Park, NC, USA
A surface enhanced Raman spectroscopy based device for rapid and minimally invasive diagnosis of neonatal infection
A surface enhanced Raman spectroscopy based device for rapid and minimally invasive diagnosis of neonatal infection
Nanyang Technological University Singapore
3M: Mobiles for Maternal health in Mali

Most women in rural Mali give birth at home and with limited assistance, due to unmanageable distances between communities and health facilities, unsupported community health workers and the inability of the health system to track pregnant women and respond to high risk and emergency cases. As a result, Mali has one of the highest maternal mortality rates in the world.

3M: Mobiles for Maternal health in Mali
Aga Khan Foundation USA Washington, DC USA
Scaling-Up of Mobile Technology for Community Health (MOTECH) in Ghana

Grameen Foundation, in partnership with Ghana Health Service, is requesting support to expand the successfully piloted MOTECH (Mobile Technology for Community Health) initiative to two new districts in a transition plan towards national scale-up. The program will reach approximately 14,000 pregnant women and 46,000 children under five over the two-year implementation, increasing access to accurate health information, generating increased demand for antenatal, postnatal and neonatal care, and providing detailed data on health service delivery and outcomes to Ghana Health Service.

Scaling-Up of Mobile Technology for Community Health (MOTECH) in Ghana
Grameen Foundation USA Washington, DC USA
Scaling proven mobile maternal health e-vouchers in Western Kenya

Our plan is to scale up a proven e-voucher program covering the costs of maternity care and SMS reminders in order to reduce financial and informational barriers to care and to dramatically increase skilled facility-based deliveries. Specifically, we plan to (1) double the rates of institutional and skilled deliveries; (2) increase the rates of antenatal and postnatal care, particularly the number of women who receive four or more antenatal visits; (3) improve the quality of care delivered by incentivizing CHWs; and integrate our vouchers with a Government health financing plan.

Scaling proven mobile maternal health e-vouchers in Western Kenya
Changamka Microhealth Nairobi, Kenya
Assessing the Effectiveness of Cash Transfers on Increasing Use of Maternal and Newborn Services in Mozambique

Equity is key to reducing maternal and child mortality in Mozambique. The country still presents significant gaps between the richest and the poorest quintile for key MNCHN interventions: Skilled birth attendance is estimated at 55.3%, but only at 36.1% in the poorest quintile of the population (MICS 2008).

Assessing the Effectiveness of Cash Transfers on Increasing Use of Maternal and Newborn Services in Mozambique
Save the Children Federation, Inc. Westport, CT USA
Testing and development of the Infant Respiratory Rate Sensor (IRRS) device to improve the identification of sick neonates in developing countries

The World Health Organization (WHO) recommends that when skilled health workers are not available, trained community health workers (CHW) who are linked to the health care system can conduct home visits to screen for and refer neonates with danger signs. Most of the signs that WHO recommends that CHWs look for can be assessed by simple observation or by asking the mother. The exceptions are fast breathing, which requires counting and the use of a timer or watch, and high/low temperature, which requires the use of a thermometer.

Testing and development of the Infant Respiratory Rate Sensor (IRRS) device to improve the identification of sick neonates in developing countries
PROJECT HOPE-THE PEOPLE-TO-PEOPLE HEALTH FOUNDATION, INC. Millwood, VA, USA
Project BRITE: Better Results through Integrated Technology and Empowerment

PCI and ZMQ have designed an m-health application that has the potential to substantially and sustainably reduce stillborn, maternal and/or newborn deaths not only in Moradabad, UP, but throughout India and beyond. The Universal Patient Management and Analysis System (UPMAS) is designed to overcome the weaknesses of similar approaches to date by boldly overcoming the intransient barriers to access and delivery of quality maternal, child and neonatal health (MCNH) services for true behavior change and significant long term impact.

Project BRITE: Better Results through Integrated Technology and Empowerment
Project Concern International (dba PCI) San Diego, CA USA
PPH prevention program in Western Nepal

Based on ten years of operation in Tibet, One Heart Worldwide (OHW) has developed Network of Safety an effective, replicable and sustainable training and outreach model to prevent maternal and newborn death associated with pregnancy and delivery among remote rural populations. The Network of Safety is a culturally adaptable program that teaches basic life-saving skills to all the community members and health care providers surrounding a new mother and her infant. In 2008, the program reached a sustainable level and was successfully transferred to local partners.

PPH prevention program in Western Nepal
One Heart World-Wide San Francisco, CA USA
Point of care diagnostic tools for prevention and care package to reduce infant mortality

Each year in sub-Saharan Africa 880,000 babies are stillborn and 1 million die in the first week of life. Many of these deaths are due to maternal infection with HIV, syphilis or malaria, or to maternal anaemia, which cause stillbirth, preterm birth and low birth weight, increasing the risk of neonatal death. In rural Tanzania, as in many other African countries, more than 80% of pregnant women attend antenatal clinic, but few are screened and treated for these conditions – an important missed opportunity to save newborn lives.

Point of care diagnostic tools for prevention and care package to reduce infant mortality
London School of Hygiene and Tropical Medicine London, England
JustMilk - Development of an Infant Nipple Shield Drug Delivery System Used During Breastfeeding

New drug delivery methods for infants are needed in low- and middle-income countries. Each year over three million babies die within the first month after birth, with the risk of death highest during the initial hours and days. Most of these deaths are easily preventable by early administration of drugs or nutrients [WHO/PMNCH "Millennium Development Goal 4" Fact Sheet, 2011]. We propose to develop a low-cost Nipple Shield Delivery System (NSDS) to administer drugs or nutrients to breastfeeding infants via easily disintegrating tablets within a modified nipple shield.

JustMilk - Development of an Infant Nipple Shield Drug Delivery System Used During Breastfeeding
University of Cambridge (on behalf of Justmilk) Cambridge, Cambridgeshire, UK
Healthy Baby Djangi Funds (HBDFs) Save Lives in Cameroon

Cameroon has made a package of priority prenatal and delivery services available to pregnant women at a partially subsidized cost, but still has some of the worst maternal mortality rates and neonatal mortality rates in Africa (782 per 100,000 and 33 per 1000 respectively). A large percentage of pregnant women, particularly in rural areas, are not accessing available services because of remaining financial and informational barriers. This project enables pregnant women to self-insure transportation costs and co-payment fees associated with their pregnancy and delivery care.

Healthy Baby Djangi Funds (HBDFs) Save Lives in Cameroon
Medicines for Humanity Rockland, MA, USA
Bolivia Delivers: Labor & Delivery in a Box

Medical doctors and registered nurses who work with birthing mothers in rural, developing countries have had their hands tied for too long; they need better monitoring equipment and the education to use that equipment to generate data that will allow them to more effectively treat expectant mothers. The Bolivia Delivers project proposes to develop a low cost, portable maternal and fetal monitoring system that will allow rural practitioners to make decisions based on trends that occur over time in their patients’ physiological data.

Bolivia Delivers: Labor & Delivery in a Box
Idaho State University Pocatello, ID USA
Testing and development of the INSPIRE device to improve the identification of sick neonates in developing countries.

The World Health Organization (WHO) recommends that when skilled health workers are not available, trained community health workers (CHW) who are linked to the health care system conduct home visits to screen/refer neonates with danger signs. Most of the signs that WHO recommends CHWs look for can be assessed by simple observation or by asking the mother. The exceptions are fast breathing, which requires counting and the use of a timer/watch, and a high/low temperature, which requires the use of a thermometer.

Testing and development of the INSPIRE device to improve the identification of sick neonates in developing countries.
Project HOPE Millwood, VA, USA
Low-cost disposable incubator (warmer/cooler) for reducing infant mortality and infection.

Low resource environments present many challenges for maternal and neonatal healthcare delivery, such as a lack of basic equipment to protect newborns, particularly at-risk neonates. Most rural healthcare facilities lack even a simple incubator/warmer. Additionally mothers face social pressure to return home with the infant immediately after delivery. Such cultural factors inhibit care-giving, further decreasing chances of infant survival. Through previous seed-funding from NCIIA, we built a prototype and improved it based on feedback from NGOs and rural healthcare workers in India.

Low-cost disposable incubator (warmer/cooler) for reducing infant mortality and infection.
Phoenix Medical Systems (P) Limited Chennai, Tamil Nadu, India
Development of a rectal antibiotic formulation for the community-based management of neonatal sepsis

Neonatal sepsis is the single greatest cause of preventable death in children living in tropical countries. Most deaths occur in or near home. Prompt parenteral administration of effective antibiotics is life saving, but seldom possible in the rural tropics. We propose to develop a rectal formulation of a third generation cephalosporin antibiotic for reducing mortality through early community-based management of neonatal sepsis.

Development of a rectal antibiotic formulation for the community-based management of neonatal sepsis
University of Oxford, Nuffield Dept of Clinical Medicine Oxford, England
Mobilizing Maternal Health In Rural Kenya With E-Vouchers And Information Technology

We aim to double rates of skilled assistance at birth and dramatically improve maternal and child health outcomes in rural areas of Kenya’s Western Province by using an integrated solution that empowers poor women to overcome financial and informational barriers to life-saving health services.   We will administer a system of subsidized pre-paid e-vouchers and transportation subsidies delivered via mobile phone, as well as informational interventions, including SMS messaging, participatory networks, and radio.

Mobilizing Maternal Health In Rural Kenya With E-Vouchers And Information Technology
Changamka Microhealth Ltd Nairobi, Kenya
Old disease, new technology: Winning the syphilis battle with mHealth and community based agents

Rationale: An estimated 50% of maternal syphilis infections result in stillbirth or congenital infection. Affordable rapid testing and effective treatment exist; the challenge lies in boosting screening and ensuring treatment for hard-to-reach mothers. Measuring the success of service delivery models is challenging; a low-cost test is needed to accurately measure the rate of newborn transmission in addition to the current method of counting stillbirths, a poor surrogate of congenital syphilis (CS) infection.

Old disease, new technology: Winning the syphilis battle with mHealth and community based agents
Boston University, BUMC Boston, MA USA
Development of the Hemafuse Autologous Transfusion Device to Treat Ruptured Ectopic Pregnancies in Sub-Saharan Africa

Hemorrhage is the leading cause of maternal mortality in the first trimester across Sub-Saharan Africa, often due to ectopic pregnancies. Over 20,000 of cases occur in Ghana with 87% of these becoming ruptured ectopic pregnancies. During a ruptured case, 1/3 of the mother’s blood pools in her abdomen causing acute anemia and a high risk for mortality. Due to a lack of donor blood and appropriate equipment, the women’s own blood must be transfused through a procedure that relies on a soup ladle and gauze.

Development of the Hemafuse Autologous Transfusion Device to Treat Ruptured Ectopic Pregnancies in Sub-Saharan Africa
Sisu Global Health Troy, MI, USA
Demanding Better: Demand generation and service provision to save lives at birth in Johannesburg

In South Africa, the maternal mortality ratio is estimated to be 310 per 100000 live births, a number which is high due in large part to many women not attending antenatal care or not doing so before 20 weeks into their pregnancy. Late attendance is due to a number of factors including women's lack of understanding of the benefits. Given the high rates of HIV, TB, and hypertension within South Africa, it is important for these high-risk pregnancies to be identified early.

Demanding Better: Demand generation and service provision to save lives at birth in Johannesburg
Wits Health Consortium Johannesburg, South Africa
Mobile Lotteries for Safe Births in Bangladesh & Kenya

In this decade, reproductive health voucher programs have successfully reduced maternal and infant mortality and morbidity through the innovative financing of reproductive health services.

Mobile Lotteries for Safe Births in Bangladesh & Kenya
Gobee Group, LLC Bellevue, WA USA
Linking Preterm Infants with Special Care in rural Bangladesh: Improving Identification and Management of Babies "Born too soon"

Complications of preterm birth are the leading cause of neonatal mortality globally. Our aim is to improve early recognition of preterm infants in a setting with 90% home birth and to link these high-risk babies with effective interventions to reduce neonatal morbidity and mortality. For SL@B1 and in collaboration with the World Health Organization, we are currently validating a range of methods to identify preterm infants by first-level health workers. To transition to scale, our next step is "proof-of-concept" of the final preterm assessment.

Linking Preterm Infants with Special Care in rural Bangladesh: Improving Identification and Management of Babies "Born too soon"
The Brigham and Women's Hospital Boston, MA, USA
Fast tracking progress to reduce Maternal and Child Mortality: Removing Barriers to Seeking, Reaching and Giving Care

It is very well possible to reduce maternal and neonatal death by ICT, mobile phones, performance based financing and task shifting. Although there is progress in these areas in Uganda, there are still factors contributing to the death of pregnant or birth-giving women and newborn children like hemorrhage, sepsis/infection, hypertension, preterm birth and tetanus. Interventions to avoid or prevent problems such as lack of correct information, a skilled attendant and access to quality health care still show gaps.

Fast tracking progress to reduce Maternal and Child Mortality: Removing Barriers to Seeking, Reaching and Giving Care
Health Child Kampala, Uganda
Rapid diagnosis of frail and sick newborns with a handheld vital sign monitor

Nearly half of all infant deaths occur in the first 28 days after birth, with intrauterine growth restriction, prematurity, low birth weight, hypothermia, and sepsis as leading causes. Rapid and reliable identification of frail and sick newborns is critical to saving lives. Current algorithms used by community health workers for integrated management of neonatal and child illness can identify up to 50% of frail newborns. However, this leaves 50% undetected even under ideal conditions of worker quality and performance. Improved ability to detect IUGR and frail and sick newborns is needed.

Rapid diagnosis of frail and sick newborns with a handheld vital sign monitor
President and Fellows of Harvard College Boston, MA, USA
Development of a Low-Cost, Bubble CPAP Kit and Oxygen Blender

Each year worldwide, millions of preterm infants (born before 37 weeks gestation) are born, many with lung immaturity that leads to respiratory distress syndrome, a major cause of morbidity and mortality. In the developed world, infants such as these are supported with continuous positive airway pressure (CPAP) devices, obviating the need for mechanical ventilation, which requires placement of a tube in the trachea that can cause lasting damage to the airways.

Development of a Low-Cost, Bubble CPAP Kit and Oxygen Blender
Program for Appropriate Technology in Health (PATH) Seattle, WA USA
Effect of Zinc as an Adjuvant Therapy for the Treatment of Neonatal Sepsis (NS) in Bangladesh

Rationale: More than one-quarter of neonatal deaths are due to neonatal sepsis (NS). NS is usually treated with parenteral and oral antibiotics but case fatality rates are high. It was shown that Zinc ions are crucial for multiple aspects of the immune system, including the normal development, differentiation, and function of cells belonging to both innate and acquired immunity. Modulation of immune response by oral Zinc supplementation is considered as a single approach for multiple diseases.

Effect of Zinc as an Adjuvant Therapy for the Treatment of Neonatal Sepsis (NS) in Bangladesh
International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) Dhaka, Bangladesh
Novel Therapeutics for Preeclampsia in the Developing World
Novel Therapeutics for Preeclampsia in the Developing World
University of Florida Gainesville, FL USA
Recharging IFA-CA: Introducing maternal and newborn superpack to increase adherence and early uptake of IFA and Calcium

“Recharging IFA-Calcium” seeks to reduce risks to maternal and newborn health posed by gestational iron deficiency anemia (low birth weight and very premature birth) and pre-eclampsia, by addressing low-adherence to and late uptake of WHO-endorsed gestational supplementation regimes of iron and folic acid (IFA) and calcium (Ca).

Recharging IFA-CA: Introducing maternal and newborn superpack to increase adherence and early uptake of IFA and Calcium
Micronutrient Initiative Ottowa, Ontario, Canada
Point-Of-Care Nucleic Acid Diagnostic For Early Infant Diagnosis Of HIV

Immediate antiretroviral therapy (ART) for HIV-infected infants has been shown to reduce mortality by 76% and progression to more serious disease by 75%. Accessing this life-saving treatment is contingent upon diagnosis of infection, which can be difficult in low-resource settings. Early infant diagnosis (EID) of HIV requires detection of viral RNA through nucleic acid amplification tests (NAATs), which are limited to well-funded, centralized facilities.

Point-Of-Care Nucleic Acid Diagnostic For Early Infant Diagnosis Of HIV
Diagnostics For All Cambridge, MA, USA
Prenatal calcium to prevent preeclampsia and preterm birth in resource-poor rural settings

Problem: Hypertensive diseases of pregnancy (HDP) and preterm birth (PB) are major causes of maternal and newborn death, particularly in rural settings where access to emergency obstetric and neonatal care is limited.

Prenatal calcium to prevent preeclampsia and preterm birth in resource-poor rural settings
The Hospital for Sick Children Toronto, Canada
Measuring, then mitigating, the health effects of the common practice of yu fai (mother roasting) for recent parity women and their babies in Lao PDR.

Lao PDR is well short of the 2015 targets for MDGs 4 and 5. It has one of the highest Maternal and Infant Mortality ratios in the Western Pacific Region. Furthermore the levels of maternal and infant morbidity, especially from pneumonia and other respiratory infections, are very high. A key likely contributor to post-parity maternal and infant deaths and morbidity is exposure, for both mothers and infants, to extreme heat and smoke pollution during the yu fai process (mother roasting) which is practiced by over 90% of Lao families for up to 45 days after birth.

Measuring, then mitigating, the health effects of the common practice of yu fai (mother roasting) for recent parity women and their babies in Lao PDR.
Deakin University Geelong, Australia
Increasing Antenatal Service Use at Scale: Are service-delivery improvements or demand-creation incentives more effective?

In Nyanza Province, Kenya, of every 1000 live births, 5 mothers and 39 newborns die, largely because of underdeveloped systems to distribute information, goods, and services to poor women. With a stage 2 SL@B seed grant we implemented an integrated program to address the interrelated factors leading to poor maternal and infant health. On the service-delivery side, we provided Helping Mothers Survive and Helping Babies Breathe training to health providers and emergency obstetric and hygiene supplies to clinics.

Increasing Antenatal Service Use at Scale: Are service-delivery improvements or demand-creation incentives more effective?
RAND Corporation United States
From Opposers to Champions of Maternal and Neonatal Health

This project confronts the barriers to maternal and neo-natal health constructed and maintained by some community and religious leaders (CRLs) in six states of Nigeria. CRLs provide the ideology, messages and personal life examples which counter the myriad maternal and neonatal health interventions in this region. Previous interventions avoided resistant CRLs, engaging only liberal scholars in one-off events such as workshops. This has failed to bring down the barriers and the death rates persist.

From Opposers to Champions of Maternal and Neonatal Health
Development Research and Projects Center (dRPC) Kano, Nigeria
DigiHealth - Haiti Maternal Health Network

While over 80% of Haitian adults have access to mobile phones, less than 20% of Haitian woman have access to health care. Our goal is to substantially increase health care access by creating a maternal healthcare network. The DigiHealth network combines a support/call center, healthcare software and mobile computing with the brand, scale, and infrastructure of Digicel, Haiti’s largest mobile carrier.

DigiHealth - Haiti Maternal Health Network
Univicity, L3C Yorba Linda, CA USA
Low-Cost Respiratory Support: Reducing Early Neonatal Death in Malawi

Rationale: Acute respiratory infections are the leading cause of global child mortality.  In the developing world, oxygen therapy is often the only treatment for babies suffering from respiratory distress (RDS).  Without the added pressure of bubble Continuous Positive Airway Pressure (bCPAP), babies struggle to breathe and can suffer serious complications, and frequently death.  A stand-alone bCPAP device can cost $6,000, too expensive for most developing world hospitals.  

Low-Cost Respiratory Support: Reducing Early Neonatal Death in Malawi
William Marsh Rice University Houston, TX USA
Strip test for glycated albumin screening

Rationale: Gestational Diabetes Mellitus (GDM) is a rapidly growing problem in many developing countries that demands appropriate diagnostic technology. GDM leads to serious complications for both mother and baby, and also predisposes both to developing Type 2 diabetes. Recommended screening for GDM is the Oral Glucose Challenge Test (OGCT). This requires fasting and several hours at the clinic for glucose measurements, leading to low patient compliance. Implementing the OGCT in developing countries has been only moderately successful in pilot studies.

Strip test for glycated albumin screening
Program for Appropriate Technology in Health (PATH) Seattle, WA USA
Testing Calcium Supplementation Through Community Based Service Delivery Mechanisms to Prevent Preeclampsia

Preeclampsia is the leading cause of maternal death in Nepal and daily calcium consumption has been proven in a clinical setting to reduce preeclampsia. Unfortunately, daily consumption of calcium is not typical in rural and disadvantaged communities in Nepal. In order to improve calcium distribution, delivery methods must be community-based and combined with behavior change strategies.

Testing Calcium Supplementation Through Community Based Service Delivery Mechanisms to Prevent Preeclampsia
Plan International USA, Inc. Washington, DC, USA
Mareezbar (Patient-carriage) - a varsatile all-terrain carriage for transporting maternal cases to health facilities

The essence of our idea is perfecting and field testing Mareezbar (Patient Carriage), a low cost, versatile and universal mean of transporting maternal cases to health facilities to overcome the second delay in receiving maternal care, the most important one in Afghanistan. The second delay in the Three Delays Model originates from: 1) unavailability of and cost of transportation; 2) long distance to health centers and hospitals; 3) poor roads; 4) difficult geography e.g. mountainous terrain, rivers; and 5) and inadequate of referral systems.

Mareezbar (Patient-carriage) - a varsatile all-terrain carriage for transporting maternal cases to health facilities
Silk Route Training and Research Organization Kabul, Afghanistan
Waterless Hand Cleansing with Chlorhexidine: a Novel Approach to Prevent Neonatal Deaths

The youngest of babies are the ones most likely to die, often from preventable infections. Handwashing can prevent infections in early childhood. The usual ways to promote handwashing with soap and water are failing - they do not change individuals' behaviors sufficient to impact health. An innovative but low-cost and low-technology solution, chlorhexidine for waterless hand cleansing, could yield dramatic improvements in hand cleansing among mothers and birth attendants, rather than the small changes that typically result from promotion of handwashing with water and soap.

Waterless Hand Cleansing with Chlorhexidine: a Novel Approach to Prevent Neonatal Deaths
The Research Foundation of the State University of New York Buffalo, NY USA
Baby Monitor: Connecting women and infants to care

Baby Monitor, a mobile interactive voice response system, will bring clinical assessment and referrals directly to mothers and their infants in resource-poor settings who are unlikely to access routine care. To date, mobile applications largely have been used to send patient reminders and health information or to collect patient information through intermediaries such as community health workers. Patients in developing countries have not been end-users of mobile diagnostic tools and medical record systems.

Baby Monitor: Connecting women and infants to care
Population Council New York, NY USA
An Investigation of Smart Phone Application in Emergency Obstetric and Newborn Care in Ghana

Our idea is to reduce by half the incidence of postpartum hemorrhage (PPH), fresh stillbirths, and early neonatal deaths in a clinical trial by improving Ghanaian delivery personnel's clinical management of these emergencies via a low-cost smart phone intervention. Training of delivery staff can reduce by half the incidence of PPH, stillbirth, and early neonatal deaths. In Ghana, however, there is no ongoing training program due to cost limitations. Video training is no less effective than hands-on training, and smart phone training could be a feasible low-cost alternative.

An Investigation of Smart Phone Application in Emergency Obstetric and Newborn Care in Ghana
Aarhus University Aarhus, Denmark
SWIFTCare - Supporting Women, Infants and Families in Timely Care Seeking for Maternal and Neonatal Health

Catholic Relief Services, in collaboration with local implementation partners the Nicaragua Ministry of Health (MoH) and Caritas Matagalpa, and supported by researchers at John Hopkins Bloomberg School of Public Health and the Sustainable Sciences Institute, proposes to scale up a proven integrated solution that optimizes birth outcomes in the poorest and most remote communities of Matagalpa, Nicaragua where high maternal and neonatal mortality continues to be a critical problem.

SWIFTCare - Supporting Women, Infants and Families in Timely Care Seeking for Maternal and Neonatal Health
Catholic Relief Services, USCCB Baltimore, MD USA
Saving in Central Malawi through empowering communities, health workers, managers and leaders

A major gap exists between what is known – the evidence base for effective maternal and neonatal health (MNH) – and what is practiced, especially in low- and middle-income countries. Interventions that can effectively close this gap in these settings depend on community engagement, reliable health systems, and effective leadership. Over the past four years, the Malawian NGO, MaiKhanda, has tested ways to improve health system effectiveness for MNH.

Saving in Central Malawi through empowering communities, health workers, managers and leaders
Institute for Healthcare Improvement Cambridge, MA USA